• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Identification of an enhancer element of class Pi glutathione S-transferase gene required for expression by a co-planar polychlorinated biphenyl.鉴定共平面多氯联苯表达所需的Pi类谷胱甘肽S-转移酶基因的增强子元件。
Biochem J. 1999 Mar 15;338 ( Pt 3)(Pt 3):599-605.
2
Epidermal growth factor regulation of glutathione S-transferase gene expression in the rat is mediated by class Pi glutathione S-transferase enhancer I.大鼠中表皮生长因子对谷胱甘肽S-转移酶基因表达的调控是由Pi类谷胱甘肽S-转移酶增强子I介导的。
Biochem J. 2000 Jul 1;349(Pt 1):225-30. doi: 10.1042/0264-6021:3490225.
3
Analysis of glutathione transferase P gene regulation with liver cells in primary culture.
Cell Growth Differ. 1992 Oct;3(10):685-91.
4
Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.通过普鲁卡因胺处理使人类前列腺癌细胞中GSTP1 CpG岛高甲基化逆转并重新激活pi类谷胱甘肽S-转移酶（GSTP1）表达
Cancer Res. 2001 Dec 15;61(24):8611-6.
5
Effect of trans-acting factor on rat glutathione S-transferase P1 gene transcription regulation in tumor cells.
Chin Med J (Engl). 2002 Jan;115(1):103-6.
6
Activation of glutathione transferase P gene by lead requires glutathione transferase P enhancer I.铅对谷胱甘肽转移酶P基因的激活需要谷胱甘肽转移酶P增强子I。
J Biol Chem. 1996 Jan 19;271(3):1626-32. doi: 10.1074/jbc.271.3.1626.
7
Activation of mouse Pi-class glutathione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen.Nrf2（核因子E2相关因子2）和雄激素对小鼠Pi类谷胱甘肽S-转移酶基因的激活作用
Biochem J. 2002 Jun 1;364(Pt 2):563-70. doi: 10.1042/BJ20011756.
8
Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells.在MDA PCa 2a和MDA PCa 2b细胞中沉默π类谷胱甘肽S-转移酶
Prostate. 2002 Jun 1;51(4):225-30. doi: 10.1002/pros.10093.
9
Identification of an enhancer responsible for tumor marker gene expression by means of transgenic rats.
Cancer Res. 1995 Jun 15;55(12):2651-5.
10
[Study on cis-acting elements of rat glutathione S-tranferase P1 gene].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1998 Oct;20(5):321-6.

引用本文的文献

1
Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice.空间转录组分析揭示了神经毒性物质多氯联苯（PCBs）对成年小鼠大脑的分子影响。
bioRxiv. 2025 Jul 26:2025.07.24.665575. doi: 10.1101/2025.07.24.665575.
2
Does glutathione S-transferase Pi (GST-Pi) a marker protein for cancer?谷胱甘肽S-转移酶Pi（GST-Pi）是癌症的标志物蛋白吗？
Mol Cell Biochem. 2003 Nov;253(1-2):319-27. doi: 10.1023/a:1026036521852.
3
Epidermal growth factor regulation of glutathione S-transferase gene expression in the rat is mediated by class Pi glutathione S-transferase enhancer I.大鼠中表皮生长因子对谷胱甘肽S-转移酶基因表达的调控是由Pi类谷胱甘肽S-转移酶增强子I介导的。
Biochem J. 2000 Jul 1;349(Pt 1):225-30. doi: 10.1042/0264-6021:3490225.

本文引用的文献

1
Transcriptional regulation of mammalian genes in vivo. A tale of two templates.哺乳动物基因在体内的转录调控。两个模板的故事。
J Biol Chem. 1997 Oct 31;272(44):27493-6. doi: 10.1074/jbc.272.44.27493.
2
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.Nrf2/小Maf异二聚体通过抗氧化反应元件介导II期解毒酶基因的诱导。
Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22. doi: 10.1006/bbrc.1997.6943.
3
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.谷胱甘肽S-转移酶超基因家族：谷胱甘肽S-转移酶的调控及其同工酶在癌症化学保护和耐药性中的作用。
Crit Rev Biochem Mol Biol. 1995;30(6):445-600. doi: 10.3109/10409239509083491.
4
Phosphorylation of c-Jun stimulated in primary cultured rat liver parenchymal cells by a coplanar polychlorinated biphenyl.一种共面多氯联苯刺激原代培养大鼠肝实质细胞中c-Jun的磷酸化。
Biochem J. 1996 Feb 1;313 ( Pt 3)(Pt 3):863-6. doi: 10.1042/bj3130863.
5
Developmental effects of dioxins and related endocrine disrupting chemicals.
Toxicol Lett. 1995 Dec;82-83:743-50. doi: 10.1016/0378-4274(95)03592-3.
6
Teratogenicity and immunotoxicity of 3,3',4,4',5-pentachlorobiphenyl in C57BL/6 mice.
Toxicology. 1993 Jan 29;77(1-2):123-31. doi: 10.1016/0300-483x(93)90143-g.
7
Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.芳烃受体及二噁英诱导的[Ah]基因簇在毒性、癌症及信号转导中的作用。
Ann N Y Acad Sci. 1993 Jun 23;685:624-40. doi: 10.1111/j.1749-6632.1993.tb35928.x.
8
Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.二噁英反应增强子处的蛋白质-DNA相互作用。对配体化芳烃受体的六个真正DNA结合位点的分析。
J Biol Chem. 1993 Mar 25;268(9):6575-80.
9
Expression of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by coplanar polychlorinated biphenyl congeners is suppressed by protein kinase inhibitors and dexamethasone.
FEBS Lett. 1993 Oct 25;333(1-2):114-8. doi: 10.1016/0014-5793(93)80386-9.
10
Cellular sources of glutathione S-transferase P in primary cultured rat hepatocytes: localization by in situ hybridization.
Biochem J. 1994 Apr 1;299 ( Pt 1)(Pt 1):79-83. doi: 10.1042/bj2990079.

鉴定共平面多氯联苯表达所需的Pi类谷胱甘肽S-转移酶基因的增强子元件。

Identification of an enhancer element of class Pi glutathione S-transferase gene required for expression by a co-planar polychlorinated biphenyl.

作者信息

Matsumoto M, Imagawa M, Aoki Y

机构信息

Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-0053, Japan.

出版信息

Biochem J. 1999 Mar 15;338 ( Pt 3)(Pt 3):599-605.

PMID:10051428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1220092/
Abstract

3,3',4,4',5-Pentachlorobiphenyl (PenCB), one of the most toxic co-planar polychlorinated biphenyl congeners, specifically induces class Pi glutathione S-transferase (GSTP1) as well as cytochrome P-450 1A1 in primary cultured rat liver parenchymal cells [Aoki, Matsumoto and Suzuki (1993) FEBS Lett. 333, 114-118]. However, the 5'-flanking sequence of the GSTP1 gene does not contain a xenobiotic responsive element, to which arylhydrocarbon receptor binds. Using a chloramphenicol acetyltransferase assay we demonstrate here that the enhancer termed GSTP1 enhancer I (GPEI) is necessary for the stimulation by PenCB of GSTP1 gene expression in primary cultured rat liver parenchymal cells. GPEI is already known to contain a dyad of PMA responsive element-like elements oriented palindromically. It is suggested that a novel signal transduction pathway activated by PenCB contributes to the stimulation of GSTP1 expression.

摘要

3,3',4,4',5-五氯联苯（PenCB）是毒性最强的共平面多氯联苯同系物之一，它能在原代培养的大鼠肝实质细胞中特异性诱导Pi类谷胱甘肽S-转移酶（GSTP1）以及细胞色素P-450 1A1的产生[Aoki、Matsumoto和Suzuki（1993年），《欧洲生物化学学会联合会快报》333卷，第114 - 118页]。然而，GSTP1基因的5'侧翼序列并不包含芳烃受体结合的外源性反应元件。在此，我们通过氯霉素乙酰转移酶分析证明，名为GSTP1增强子I（GPEI）的增强子对于PenCB刺激原代培养的大鼠肝实质细胞中GSTP1基因表达是必需的。已知GPEI含有一对呈回文排列的佛波酯反应元件样元件。有人提出，由PenCB激活的一条新的信号转导途径有助于刺激GSTP1的表达。