Xie X, Gidding S S, Gardin J M, Bild D E, Wong N D, Liu K
Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
J Am Soc Echocardiogr. 1995 Nov-Dec;8(6):771-9. doi: 10.1016/s0894-7317(05)80001-x.
Doppler transmitral flow velocities have been used to assess left ventricular diastolic function. Associations of transmitral velocities with specific physiologic variables and cardiovascular risk factors have not been reported previously in a large population-based study of young adults. We performed Doppler analysis of left ventricular inflow in 3492 black and white men and women (aged 23 to 35 years) in the year-5 examination of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. First third filling fraction, peak flow velocity in early diastole (PFVE), peak flow velocity in late diastole (PFVA), and the PFVA/PFVE ratio were measured. Women had higher PFVE and PFVA than had men (PFVE: 0.81 +/- 0.13 m/sec versus 0.76 +/- 0.13 m/sec; PFVA: 0.47 +/- 0.11 m/sec versus 0.43 +/- 0.10 m/sec; both p < 0.001). Gender-specific multiple regression analyses showed that age, heart rate, systolic blood pressure, left ventricular percent fractional shortening, and body weight were independently and positively related to PFVA (all p < 0.001) in men and women. Age, heart rate, and forced expiratory lung capacity in 1 second were inversely related to PFVE and first third filling fraction (both p < 0.01). Left ventricular percent fractional shortening was positively related to PFVE and first third filling fraction (p < 0.001). Age, heart rate, and body weight were positively correlated with the PFVA/PFVE ratio (all p < 0.001). Height had weak negative associations with PFVA and PFVE in women only. These results suggest that, in young adults, Doppler measures of left ventricular diastolic filling are related to age, sex, body weight, blood pressure, heart rate, left ventricular systolic function, and lung function.
二尖瓣血流速度已被用于评估左心室舒张功能。在先前一项基于大规模人群的年轻成年人研究中，尚未报告二尖瓣速度与特定生理变量及心血管危险因素之间的关联。在年轻人冠状动脉风险发展研究（CARDIA研究）的第5年检查中，我们对3492名黑人和白人男性及女性（年龄23至35岁）进行了左心室流入道的多普勒分析。测量了前三分之一充盈分数、舒张早期峰值流速（PFVE）、舒张晚期峰值流速（PFVA）以及PFVA/PFVE比值。女性的PFVE和PFVA高于男性（PFVE：0.81±0.13米/秒对0.76±0.13米/秒；PFVA：0.47±0.11米/秒对0.43±0.10米/秒；两者p<0.001）。性别特异性多元回归分析显示，年龄、心率、收缩压、左心室缩短分数百分比和体重与男性和女性的PFVA均呈独立正相关（所有p<0.001）。年龄、心率和1秒用力呼气肺活量与PFVE和前三分之一充盈分数呈负相关（两者p<0.01）。左心室缩短分数百分比与PFVE和前三分之一充盈分数呈正相关（p<0.001）。年龄、心率和体重与PFVA/PFVE比值呈正相关（所有p<0.001）。身高仅与女性的PFVA和PFVE呈弱负相关。这些结果表明，在年轻成年人中，左心室舒张期充盈的多普勒测量值与年龄、性别、体重、血压、心率、左心室收缩功能和肺功能有关。
