双嘧达莫对血小板功能的影响：与人体血液水平的相关性。
The effect of dipyridamole on platelet function: correlation with blood levels in man.
作者信息
Rajah S M, Crow M J, Penny A F, Ahmad R, Watson D A
出版信息
Br J Clin Pharmacol. 1977 Apr;4(2):129-33. doi: 10.1111/j.1365-2125.1977.tb00683.x.
Abstract
1 The effect on platelet functions of dipyridamole (a pyrimido-pyrimidine compound) was compared with a control group of patients taking warfarin. 2 Adhesion, aggregation and platelet factor 4 availability showed a significant decrease in the dypyridamole group. 3 Aggregation and platelet factor 4 showed a significant correlation with blood dipyridamole level. 4 Adhesion, aggregation and platelet factor 4 were reduced below the lower limit of normal at blood dipyridamole levels above 3.5 micronmol/1.
摘要
- 将双嘧达莫（一种嘧啶并嘧啶化合物）对血小板功能的影响与服用华法林的对照组患者进行了比较。2. 双嘧达莫组的黏附、聚集和血小板因子4活性显著降低。3. 聚集和血小板因子4与血液中双嘧达莫水平呈显著相关性。4. 当血液中双嘧达莫水平高于3.5微摩尔/升时，黏附、聚集和血小板因子4降低至正常下限以下。
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本文引用的文献
1
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Nature. 1962 Jun 9;194:927-9. doi: 10.1038/194927b0.
2
3
Effect of a pyrimidopyrimidine derivative on thrombus formation in the rabbit.一种嘧啶并嘧啶衍生物对家兔血栓形成的影响。
Nature. 1965 Oct 16;208(5007):255-7. doi: 10.1038/208255a0.
4
The effect on dipyridamole on platelet aggregation and adhesiveness.双嘧达莫对血小板聚集和黏附性的影响。
Scott Med J. 1968 Dec;13(12):409-15. doi: 10.1177/003693306801301202.
5
Rôle of platelets in thrombosis.血小板在血栓形成中的作用。
Thromb Diath Haemorrh Suppl. 1966;21:131-58.
6
Platelet and fibrinogen consumption in man.人体中血小板和纤维蛋白原的消耗
N Engl J Med. 1972 Nov 16;287(20):999-1005. doi: 10.1056/NEJM197211162872001.
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Platelet survival in patients with homograft and prosthetic heart valves. Correlation with incidence of thromboembolism.同种异体移植和人工心脏瓣膜患者的血小板存活情况。与血栓栓塞发生率的相关性。
Thorax. 1974 Nov;29(6):639-42. doi: 10.1136/thx.29.6.639.
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