Cramer M J, Jaarsma W, Sutherland G R, Nihoyannopoulos P, Fioretti P, Tan L B, Schröder K, Visser C A
Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
J Am Soc Echocardiogr. 1995 Nov-Dec;8(6):854-63. doi: 10.1016/s0894-7317(05)80009-4.
This study evaluated the efficacy of computer-controlled closed-loop delivery of a new synthetic catecholamine, arbutamine, when given to induce myocardial ischemia detected by electrocardiography and echocardiography with a high (10 beats/min/min) and low (6 beats/min/min) rate of increase in heart rate (heart rate slope) in 70 patients with coronary artery disease. The electrocardiographic sensitivity for the detection of myocardial ischemia was 52% for the low slope and 51% for the high slope. The corresponding figures for echocardiographic sensitivity were 83% and 79% for the low and high slopes, respectively. There were no significant differences in changes from baseline to maximum in pharmacodynamic variables, although the mean times to reach maximum heart rate and systolic blood pressure were 1.4 minutes shorter (p = 0.001) and 3.7 minutes shorter (p < 0.05), respectively, for the high-slope regimen. The duration of the infusion was shorter (p < 0.001) for the high slope. In this study, closed-loop arbutamine administration was effective and safe in the detection of coronary artery disease for both heart rate slope regimens.
本研究评估了新型合成儿茶酚胺阿拉布胺通过计算机控制闭环给药时的疗效，该药物用于诱发70例冠心病患者的心肌缺血，通过心电图和超声心动图检测，心率升高速率（心率斜率）分为高（每分钟10次/分钟）和低（每分钟6次/分钟）两种情况。低斜率时心电图检测心肌缺血的敏感性为52%，高斜率时为51%。超声心动图检测敏感性的相应数字，低斜率和高斜率分别为83%和79%。从基线到最大值，药效学变量的变化无显著差异，尽管高斜率方案达到最大心率和收缩压的平均时间分别缩短了1.4分钟（p = 0.001）和3.7分钟（p < 0.05）。高斜率时输注持续时间更短（p < 0.001）。在本研究中，对于两种心率斜率方案，闭环输注阿拉布胺在检测冠心病方面有效且安全。
