Minford A M, Parapia L A, Stainforth C, Lee D
St Luke's Hospital, Bradford.
Br J Haematol. 1996 Apr;93(1):215-6. doi: 10.1046/j.1365-2141.1996.4691021.x.
Subcutaneous protein C concentrate (Immuno, Vienna) was used to treat a child with homozygous protein C deficiency who was formerly treated with intravenous protein C concentrate. After 3000 units subcutaneous protein C concentrate (250 iu/kg), protective protein C levels were maintained for 48 h after infusion, with peak levels at 12 h. Subcutaneous protein C concentrate is given every third day and is well tolerated by the patient. No thrombotic events have occurred. We conclude that subcutaneous administration of protein C concentrate is a valuable therapeutic option in the long-term management of homozygous protein C deficiency and avoids the potential hazards of long-term central venous lines.
皮下注射蛋白C浓缩物（Immuno，维也纳）用于治疗一名纯合子蛋白C缺乏症儿童，该儿童此前接受静脉注射蛋白C浓缩物治疗。皮下注射3000单位蛋白C浓缩物（250 iu/kg）后，输注后48小时内可维持保护性蛋白C水平，12小时达到峰值水平。皮下注射蛋白C浓缩物每三天给药一次，患者耐受性良好。未发生血栓事件。我们得出结论，皮下注射蛋白C浓缩物是纯合子蛋白C缺乏症长期管理中的一种有价值的治疗选择，可避免长期中心静脉置管的潜在风险。
