Rubegni P, Flori M L, Fimiani M, Andreassi L
Department of Dermatology, University of Siena, Italy.
Br J Haematol. 1996 Apr;93(1):217-9. doi: 10.1046/j.1365-2141.1996.4791016.x.
Cryofibrinogen is a plasma protein complex whose presence in the peripheral blood is generally asymptomatic, but may sometimes cause multiple thromboembolism in the skin, lung and myocardium. The pathological manifestations associated with cryofibrinogenaemia have been treated with plasmapheresis and fibrinolytic drugs such as streptokinase, streptodornase and/or urokinase. Good results have recently been reported with stanozolol. This prompted us to treat a patient suffering from cryofibrinogenaemia with this androgenic hormone. The patient was a 66-year-old woman with rapidly evolving leg ulcers. Stanozolol was orally administered at 4 mg b.i.d. for 5 months and then gradually reduced. Plasma cryofibrinogen disappeared after 45 d from the start of therapy and cutaneous ulcers healed in 5 months.
冷纤维蛋白原是一种血浆蛋白复合物，其在外周血中的存在通常无症状，但有时可能导致皮肤、肺和心肌的多发性血栓栓塞。与冷纤维蛋白原血症相关的病理表现已采用血浆置换和纤维蛋白溶解药物（如链激酶、链道酶和/或尿激酶）进行治疗。最近有报道称司坦唑醇治疗效果良好。这促使我们用这种雄激素激素治疗一名患有冷纤维蛋白原血症的患者。该患者是一名66岁的女性，腿部溃疡迅速发展。司坦唑醇口服给药，剂量为4mg，每日两次，持续5个月，然后逐渐减量。从治疗开始45天后血浆冷纤维蛋白原消失，皮肤溃疡在5个月内愈合。
