司坦唑醇治疗冷纤维蛋白原血症所致腿部溃疡

Stanozolol in treatment of leg ulcers due to cryofibrinogenaemia.

作者信息

Falanga V, Kirsner R S, Eaglstein W H, Katz M H, Kerdel F A

机构信息

University of Miami School of Medicine, Department of Dermatology and Cutaneous Surgery, Florida 33136.

出版信息

Lancet. 1991 Aug 10;338(8763):347-8. doi: 10.1016/0140-6736(91)90483-6.

DOI:10.1016/0140-6736(91)90483-6

PMID:1677702

Abstract

Five consecutive patients with cryofibrinogenaemia in association with painful leg ulcers and intravascular dermal thrombi were treated with stanozolol, an androgenic steroid with fibrinolytic properties. In all patients treatment was followed by rapid and striking pain relief and healing of the ulcers. Cryofibrinogenaemia was not detected on subsequent laboratory evaluation, and dermal intravascular thrombi had resolved on repeat histological examination.

摘要

五例患有冷纤维蛋白原血症并伴有腿部疼痛性溃疡和真皮内血管血栓的连续患者接受了司坦唑醇治疗，司坦唑醇是一种具有纤维蛋白溶解特性的雄激素类固醇。在所有患者中，治疗后疼痛迅速显著缓解，溃疡愈合。后续实验室评估未检测到冷纤维蛋白原血症，重复组织学检查显示真皮内血管血栓已消退。