Boffoli D, Scacco S C, Vergari R, Persio M T, Solarino G, Laforgia R, Papa S
Institute of Medical Biochemistry and Chemistry, University of Bari, Italy.
Biochim Biophys Acta. 1996 Jan 17;1315(1):66-72. doi: 10.1016/0925-4439(95)00107-7.
The activity of cytochrome-c oxidase [E.C. 1.9.3.1] and b-c1 complex [E.C. 1.10.2.2] and the content of cytochromes b, c + c1 and a + a3 in human skeletal muscle mitochondria from orthopaedic patients (108 women and 68 males), of age ranging between 10 and 50 years, have been analyzed. The activity of cytochrome c-oxidase declines with age both in females and males. The activity of b-c1 complex, which in young females is significantly higher than in young males, declines sharply in females, but not in males, with ageing. These results reveal that the content of active b-c1 complex in muscle mitochondria is specifically controlled by female sex hormones.
对年龄在10至50岁之间的骨科患者（108名女性和68名男性）的人体骨骼肌线粒体中细胞色素c氧化酶[E.C. 1.9.3.1]和b-c1复合体[E.C. 1.10.2.2]的活性以及细胞色素b、c + c1和a + a3的含量进行了分析。细胞色素c氧化酶的活性在女性和男性中均随年龄下降。b-c1复合体的活性在年轻女性中显著高于年轻男性，随着年龄增长，女性的该活性急剧下降，而男性则不然。这些结果表明，肌肉线粒体中活性b-c1复合体的含量受到女性性激素的特异性调控。
