Fujita H, Sasaki R, Yoshikawa M
Nippon Synthetic Chemical Industry Co., Ltd., Osaka, Japan.
Biosci Biotechnol Biochem. 1995 Dec;59(12):2344-5. doi: 10.1271/bbb.59.2344.
Ovokinin, a vasorelaxing octapeptide derived from ovalbumin, significantly lowered the systolic blood pressure of spontaneously hypertensive rats (SHR) when orally administered as an emulsion in 30% egg yolk at a dose of 25 mg/kg, this effect being larger than that of the peptide administered as a solution at a dose of 100 mg/kg. Egg phospholipid, especially phosphatidylcholine, showed essentially the same effect as egg yolk. However, egg neutral lipid was ineffective. Soybean phospholipid was less effective than egg phospholipid in potentiating the antihypertensive activity of ovokinin.
卵激肽是一种从卵清蛋白衍生而来的血管舒张八肽，当以25毫克/千克的剂量作为30%蛋黄乳剂口服给药时，能显著降低自发性高血压大鼠（SHR）的收缩压，这种效果比以100毫克/千克的剂量作为溶液给药的肽的效果更大。卵磷脂，尤其是磷脂酰胆碱，显示出与蛋黄基本相同的效果。然而，卵中性脂质无效。在增强卵激肽的降压活性方面，大豆磷脂比卵磷脂效果差。
