Merviel P, Antoine J M, Alvarez S, Cornet D, Plachot M, Mandelbaum J, Uzan S, Salat-Baroux J
Service de Gynécologie-Obstétrique et Fécondation in vitro, Hôpital Tenon, Paris.
Contracept Fertil Sex. 1996 Feb;24(2):157-62.
During a retrospective study on 152 singles pregnancies obtained by in vitro fecondation at Tenon hospital, and followed in this department between January 1990 and December 1994, we have studied the influence of the IVF (tubal origin, masculine or idiopathic) and the type of stimulation (human menopausal gonadotrophin: hMG or follicle stimulating hormone: FSH) on the weight of the newborn and the pathologies that occurred during the pregnancy. No difference in the antecedents has been found in the different group of patients. This study shows a significative difference (p < 0.001) of the newborn's weight when the indication of IVF is tubal origin or masculine. Also, in all IVF indications, the weight is significantly (p < 0.01) higher after a follicular stimulation by FSH versus hMG. For the pregnancy pathologies, no significative difference has been noted, although arterial hypertension, fetal growth retardation and gestational diabetes appear to be more frequent in the group of women who had stimulation by hMG.
在对152例于1990年1月至1994年12月期间在特农医院通过体外受精获得的单胎妊娠进行回顾性研究时，我们研究了体外受精的原因（输卵管因素、男方因素或不明原因）以及刺激类型（人绝经期促性腺激素：hMG或促卵泡生成素：FSH）对新生儿体重以及孕期出现的疾病的影响。在不同患者组中未发现既往史有差异。这项研究表明，当体外受精的指征为输卵管因素或男方因素时，新生儿体重存在显著差异（p < 0.001）。此外，在所有体外受精指征中，与hMG相比，使用FSH进行卵泡刺激后新生儿体重显著更高（p < 0.01）。对于孕期疾病，尽管动脉高血压、胎儿生长受限和妊娠期糖尿病在接受hMG刺激的女性组中似乎更常见，但未发现显著差异。
