Piercey S, Montanaro A
Division of Allergy and Clinical Immunology, Oregon Health Sciences University, Portland, USA.
Ann Allergy Asthma Immunol. 1996 Apr;76(4):317-20. doi: 10.1016/S1081-1206(10)60031-2.
Wegener's granulomatosis is a granulomatous systemic necrotizing vasculitis with prominent upper airway involvement. Complete remissions can be induced with aggressive management. Despite successful treatment, relapses and recurrences of active disease may occur.
We present a patient who presents with histologically confirmed active disease 17 years following successful therapy.
A case report of a 72-year-old man who initially presented at age 50 with necrotizing vasculitis of the upper and lower respiratory tract. Eighteen years following his initial therapy he presented with isolated retroorbital disease. Following re-institution of cytotoxic therapy he appears to be disease-free.
Following re-treatment with cytoxan and prednisone, a second remission was induced. The patient is currently entirely well 1 year off therapy.
Wegener's granulomatosis may recur many years following apparent successful and aggressive cytotoxic and anti-inflammatory therapy.
韦格纳肉芽肿是一种肉芽肿性全身性坏死性血管炎，上呼吸道受累明显。积极治疗可诱导完全缓解。尽管治疗成功，但仍可能发生活动性疾病的复发。
我们报告一例患者，在成功治疗17年后出现组织学确诊的活动性疾病。
病例报告，一名72岁男性，最初50岁时出现上、下呼吸道坏死性血管炎。初始治疗18年后，他出现孤立性眶后疾病。重新给予细胞毒性治疗后，他似乎无病。
用环磷酰胺和泼尼松重新治疗后，诱导了第二次缓解。患者目前停药1年，身体完全健康。
在明显成功的积极细胞毒性和抗炎治疗多年后，韦格纳肉芽肿可能复发。
