Jacquot S, Modigliani R, Kuzniak I, Boumsell L, Bensussan A
Department of Gastroenterology, Hôpital Saint-Louis, Paris, France.
Clin Immunol Immunopathol. 1996 Apr;79(1):20-4. doi: 10.1006/clin.1996.0046.
Mucosal lymphocytes are increasingly activated in Crohn's disease. In order to investigate this phenomenon we tested the response of cultured colonic mucosal T lymphocytes to CD3 activation. These lymphocytes were obtained by biopsy from control subjects and Crohn's disease patients. T cells from mucosa involved in Crohn's disease showed a higher CD3-induced proliferative response compared to control T lymphocytes (P < 0.01). T cells from uninvolved areas showed a wide range of response, ranging from normal to very high proliferative indices. Our results suggest that the exaggerated response of mucosal T lymphocytes, due to the impairment of the downregulation of the CD3-dependent signaling process, may contribute to the pathogenesis of Crohn's disease.
在克罗恩病中，黏膜淋巴细胞的激活日益增加。为了研究这一现象，我们检测了培养的结肠黏膜T淋巴细胞对CD3激活的反应。这些淋巴细胞通过活检取自对照受试者和克罗恩病患者。与对照T淋巴细胞相比，来自克罗恩病受累黏膜的T细胞表现出更高的CD3诱导增殖反应（P < 0.01）。来自未受累区域的T细胞表现出广泛的反应，增殖指数从正常到非常高不等。我们的结果表明，由于CD3依赖性信号传导过程下调受损，黏膜T淋巴细胞的过度反应可能促成了克罗恩病的发病机制。
