Qiao L, Schürmann G, Meuer S C, Autschbach F
Applied Immunology, German Cancer Research Center, Heidelberg.
Adv Exp Med Biol. 1995;371B:1287-91.
Crohn's disease is characterized by chronic inflammatory infiltrates and granuloma formation in the gut. T cell directed immunotherapy appears to be effective in relieving these symptoms. Under normal conditions, lamina propria T lymphocytes have a low proliferative response to antigen receptor stimulation in vitro due to the influence of the local intestinal environment. This study shows that lamina propria T lymphocytes exhibit an enhanced response to antigen receptor stimulation in active Crohn's disease, which may contribute in its pathogenesis.
克罗恩病的特征是肠道出现慢性炎性浸润和肉芽肿形成。针对T细胞的免疫疗法似乎对缓解这些症状有效。在正常情况下，由于局部肠道环境的影响，固有层T淋巴细胞在体外对抗原受体刺激的增殖反应较低。本研究表明，在活动性克罗恩病中固有层T淋巴细胞对抗原受体刺激的反应增强，这可能在其发病机制中起作用。
