Zabel M
Department of Histology and Embryology, Medical Academy, Poznań, Poland.
Folia Histochem Cytobiol. 1995;33(3):193-6.
The studies were performed on cultured TT cells originating from human thyroid medullary carcinoma (i.e., from parafollicular cells of the thyroid). The amount of released calcitonin was dependent upon calcium level in the medium. Moreover, calcitonin secretion might be regulated by medium supplementation with polypeptide hormones. Somatostatin inhibited while glucagon and pentagastrin stimulated calcitonin secretion to t he medium. Calcitonin secretion was also influenced by biogenic amines and their precursors. Dihydroxy-1-phenylalanine and serotonin augmented while 5-hydroxy-1-tryptophan and dopamine inhibited calcium secretion. This, calcitonin secretion may be controlled by different substances present in the healthy organism. This points to a complex control of calcium ion level in the blood.
这些研究是在源自人甲状腺髓样癌（即甲状腺滤泡旁细胞）的培养TT细胞上进行的。降钙素的释放量取决于培养基中的钙水平。此外，降钙素的分泌可能受多肽激素补充培养基的调节。生长抑素抑制，而胰高血糖素和五肽胃泌素刺激降钙素向培养基中的分泌。降钙素的分泌也受生物胺及其前体的影响。二羟基-1-苯丙氨酸和5-羟色胺增加，而5-羟基-1-色氨酸和多巴胺抑制钙分泌。因此，降钙素的分泌可能受健康机体中存在的不同物质的控制。这表明血液中钙离子水平受到复杂的调控。
