Poliakov V M, Lankin V Z, Arkhangel'skaia A V, Blagorodov S G
Biokhimiia. 1977 Mar;42(3):499-504.
Sharp increase in the content of total lipids and, especially, neutral lipids, and considerable decrease in the content of phospholipids were observed in liver microsomes and mitochondrias from liver of tumour-bearing rats in the process of the growth of sarcoma, induced by a single injection of 3,4-benzpyrene. The injection of anthracene, a non-cancerogenous hydrocarbon, practically did not affect the lipid composition of rat liver subcellular particles. Thus, the disturbances in normal functioning of subcellular particles under cancerogenesis are due to considerable change in the chemical composition of biomembranes. The data obtained confirm our hypothesis on lipid mobilization under tumour growth.
在单次注射3,4-苯并芘诱导肉瘤生长的过程中，观察到荷瘤大鼠肝脏微粒体和线粒体中总脂质尤其是中性脂质含量急剧增加，而磷脂含量显著降低。注射非致癌性碳氢化合物蒽实际上对大鼠肝脏亚细胞颗粒的脂质组成没有影响。因此，致癌过程中亚细胞颗粒正常功能的紊乱是由于生物膜化学成分的显著变化所致。所获得的数据证实了我们关于肿瘤生长过程中脂质动员的假设。
