减毒痘苗病毒-环子孢子蛋白重组体可提供针对啮齿类动物疟疾的保护作用。
Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.
作者信息
Lanar D E, Tine J A, de Taisne C, Seguin M C, Cox W I, Winslow J P, Ware L A, Kauffman E B, Gordon D, Ballou W R, Paoletti E, Sadoff J C
机构信息
Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 20307, USA.
出版信息
Infect Immun. 1996 May;64(5):1666-71. doi: 10.1128/iai.64.5.1666-1671.1996.
Abstract
NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (60 to 100%). Protection did not correlate with CS repeat-specific antibody responses and was abrogated by in vivo CD8+ T-cell depletion. Protection was not enhanced by modification of the subcellular localization of CSP. These results suggest the potential of poxvirus-based vectors for the development of vaccine candidates for human malaria.
摘要
在伯氏疟原虫啮齿动物疟疾模型系统中评估了表达环子孢子蛋白（CSP）的基于NYVAC的痘苗病毒重组体。用基于NYVAC的CSP重组体免疫小鼠可引发高水平的保护作用（60%至100%）。保护作用与CS重复序列特异性抗体反应无关，并且在体内CD8 + T细胞耗竭后被消除。CSP亚细胞定位的改变并未增强保护作用。这些结果表明基于痘病毒的载体在开发人类疟疾候选疫苗方面具有潜力。
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本文引用的文献
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Infect Immun. 1993 Sep;61(9):3933-41. doi: 10.1128/iai.61.9.3933-3941.1993.
2
Induction of cytotoxic T lymphocytes by recombinant canarypox (ALVAC) and attenuated vaccinia (NYVAC) viruses expressing the HIV-1 envelope glycoprotein.表达HIV-1包膜糖蛋白的重组金丝雀痘病毒（ALVAC）和减毒痘苗病毒（NYVAC）诱导细胞毒性T淋巴细胞。
Virology. 1993 Aug;195(2):845-50. doi: 10.1006/viro.1993.1442.
3
Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses.用高度减毒的痘苗（NYVAC）重组病毒对猪进行伪狂犬病疫苗接种。
Vet Microbiol. 1993 Dec;38(1-2):41-58. doi: 10.1016/0378-1135(93)90074-h.
4
Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.用编码环子孢子蛋白的质粒DNA免疫接种预防疟疾
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9866-70. doi: 10.1073/pnas.91.21.9866.
5
Immunization with irradiated Plasmodium berghei sporozoites induces IL-2 and IFN gamma but not IL-4.
Parasite Immunol. 1994 Sep;16(9):479-91. doi: 10.1111/j.1365-3024.1994.tb00376.x.
6
Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria.用重组流感病毒进行预处理，随后给予重组痘苗病毒，可诱导CD8 + T细胞介导的抗疟疾保护性免疫。
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5214-8. doi: 10.1073/pnas.90.11.5214.
7
Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes.携带环子孢子蛋白表位的杂交乙型肝炎病毒核心颗粒引发的疟疾免疫
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8
Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells.一氧化氮合酶的诱导对暴露于经辐照的感染伯氏疟原虫蚊子的小鼠具有抗疟保护作用：γ干扰素和CD8 + T细胞的参与。
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9
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