军团菌属的谱系，其在小鼠巨噬细胞内的增殖受Lgn1基因控制。
Spectrum of Legionella species whose intracellular multiplication in murine macrophages is genetically controlled by Lgn1.
作者信息
Miyamoto H, Maruta K, Ogawa M, Beckers M C, Gros P, Yoshida S
机构信息
Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
出版信息
Infect Immun. 1996 May;64(5):1842-5. doi: 10.1128/iai.64.5.1842-1845.1996.
Abstract
We examined the intracellular growth of 20 strains within six species of Legionella in thioglycolate-elicited peritoneal macrophages from A/J and C57BL/6 mice and a congenic strain derived from them (A.B Lgn1). With the exception of Legionella pneumophila Togus-1 and Bloomington-2, the intracellular growth of the 15 L. pneumophila strains tested was controlled by Lgn1. However, the intracellular growth of five Legionella species other than L. pneumophila was not under Lgn1's control.
摘要
我们检测了嗜肺军团菌六个菌种中的20个菌株在A/J和C57BL/6小鼠以及由此培育出的同基因品系（A.B Lgn1）经巯基乙酸盐诱导的腹腔巨噬细胞中的胞内生长情况。除嗜肺军团菌托古斯-1菌株和布卢明顿-2菌株外，所检测的15株嗜肺军团菌菌株的胞内生长受Lgn1控制。然而，除嗜肺军团菌外的其他五种军团菌的胞内生长不受Lgn1控制。
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本文引用的文献
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Temperature effects on Legionella pneumophila killing by and multiplication in phagocytes of guinea pigs.温度对豚鼠吞噬细胞杀灭嗜肺军团菌及嗜肺军团菌在吞噬细胞中增殖的影响。
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Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13.
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Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes.军团菌病细菌（嗜肺军团菌）在人类单核细胞内进行细胞内增殖。
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