来自非胞质型单核细胞增生李斯特菌的肽表位可由主要组织相容性复合体I类分子呈递。
Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class I molecules.
作者信息
Zwickey H L, Potter T A
机构信息
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206-2761, USA.
出版信息
Infect Immun. 1996 May;64(5):1870-2. doi: 10.1128/iai.64.5.1870-1872.1996.
Abstract
Listeria monocytogenes is an intracellular pathogen which escapes the phagosome and resides in the cytosol of the host cell. Using Listeria innocua and a mutant strain of L. monocytogenes (listeriolysin O negative), which do not enter the cytosol of the host cell, we demonstrate class I presentation of an epitope of p60, a protein secreted by L. monocytogenes, to a class I-restricted CD8+ cytotoxic T lymphocyte clone.
摘要
单核细胞增生李斯特菌是一种细胞内病原体，它能逃离吞噬体并存在于宿主细胞的胞质溶胶中。我们使用无害李斯特菌和单核细胞增生李斯特菌的一个突变菌株（溶血素O阴性），它们不会进入宿主细胞的胞质溶胶，证明了单核细胞增生李斯特菌分泌的一种蛋白p60的一个表位向I类限制性CD8 +细胞毒性T淋巴细胞克隆的I类呈递。
相似文献
1
Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class I molecules.来自非胞质型单核细胞增生李斯特菌的肽表位可由主要组织相容性复合体I类分子呈递。
Infect Immun. 1996 May;64(5):1870-2. doi: 10.1128/iai.64.5.1870-1872.1996.
2
3
Cytotoxic-T-lymphocyte responses to epitopes of listeriolysin O and p60 following infection with Listeria monocytogenes.单核细胞增生李斯特菌感染后细胞毒性T淋巴细胞对溶血素O和p60表位的反应
Infect Immun. 1996 Jul;64(7):2515-22. doi: 10.1128/iai.64.7.2515-2522.1996.
4
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.针对单核细胞增生李斯特菌单个九聚体表位的CD8 + T细胞在体内具有保护作用。
J Exp Med. 1992 Jun 1;175(6):1531-8. doi: 10.1084/jem.175.6.1531.
5
Efficient induction of cytotoxic CD8+ T cells against exogenous proteins: establishment and characterization of a T cell line specific for the membrane protein ActA of Listeria monocytogenes.高效诱导针对外源蛋白的细胞毒性CD8 + T细胞：针对单核细胞增生李斯特菌膜蛋白ActA的T细胞系的建立与特性分析
Eur J Immunol. 1998 Sep;28(9):2630-9. doi: 10.1002/(SICI)1521-4141(199809)28:09<2630::AID-IMMU2630>3.0.CO;2-Z.
6
Presentation of Listeria monocytogenes antigens by major histocompatibility complex class I molecules to CD8 cytotoxic T lymphocytes independent of listeriolysin secretion and virulence.单核细胞增生李斯特菌抗原由主要组织相容性复合体I类分子呈递给CD8细胞毒性T淋巴细胞，这一过程独立于李斯特菌溶血素的分泌和毒力。
Eur J Immunol. 1994 Jul;24(7):1471-7. doi: 10.1002/eji.1830240703.
7
A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes.一种直接体外表位作图的新方法可鉴定出单核细胞增生李斯特菌的显性和亚显性CD4和CD8 T细胞表位。
J Immunol. 2001 Feb 1;166(3):1877-84. doi: 10.4049/jimmunol.166.3.1877.
8
9
Delivery of class I and class II MHC-restricted T-cell epitopes of listeriolysin of Listeria monocytogenes by attenuated Salmonella.减毒沙门氏菌递送单核细胞增生李斯特菌溶血素的I类和II类主要组织相容性复合体限制性T细胞表位
Vaccine. 1995 Feb;13(2):142-50. doi: 10.1016/0264-410x(95)93127-u.
10
The role of the bacterial membrane protein ActA in immunity and protection against Listeria monocytogenes.细菌膜蛋白ActA在抗单核细胞增生李斯特菌免疫和保护中的作用。
J Immunol. 1998 Sep 1;161(5):2414-20.
本文引用的文献
1
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.蛋白酶体抑制剂可阻断大多数细胞蛋白质的降解以及主要组织相容性复合体I类分子上所呈递肽段的产生。
Cell. 1994 Sep 9;78(5):761-71. doi: 10.1016/s0092-8674(94)90462-6.
2
Cells infected with Yersinia present an epitope to class I MHC-restricted CTL.感染耶尔森氏菌的细胞向I类主要组织相容性复合体（MHC）限制的细胞毒性T淋巴细胞（CTL）呈递一个表位。
J Immunol. 1994 Aug 15;153(4):1603-12.
3
Presentation of Listeria monocytogenes antigens by major histocompatibility complex class I molecules to CD8 cytotoxic T lymphocytes independent of listeriolysin secretion and virulence.单核细胞增生李斯特菌抗原由主要组织相容性复合体I类分子呈递给CD8细胞毒性T淋巴细胞，这一过程独立于李斯特菌溶血素的分泌和毒力。
Eur J Immunol. 1994 Jul;24(7):1471-7. doi: 10.1002/eji.1830240703.
4
Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.单核细胞增生李斯特菌将病毒抗原递送至I类加工和呈递途径。
J Exp Med. 1994 Dec 1;180(6):2209-18. doi: 10.1084/jem.180.6.2209.
5
Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.巨噬细胞对外源性颗粒抗原进行吞噬处理，以便通过I类主要组织相容性复合体分子进行呈递。
J Immunol. 1994 Dec 1;153(11):4925-33.
6
CD8+ T lymphocyte-mediated lysis of Chlamydia-infected L cells using an endogenous antigen pathway.利用内源性抗原途径，CD8 + T淋巴细胞介导对衣原体感染的L细胞的裂解作用。
J Immunol. 1994 Nov 15;153(10):4588-95.
7
8
A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules.一种用于MHC I类分子呈递外源性抗原的从吞噬体到胞质溶胶的途径。
Science. 1995 Jan 13;267(5195):243-6. doi: 10.1126/science.7809629.
9
Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.重组单核细胞增生李斯特菌作为一种活疫苗载体用于诱导保护性抗病毒细胞介导免疫。
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3987-91. doi: 10.1073/pnas.92.9.3987.
10
Listeria monocytogenes p60 supports host cell invasion by and in vivo survival of attenuated Salmonella typhimurium.单核细胞增生李斯特菌p60支持减毒鼠伤寒沙门氏菌侵袭宿主细胞并在体内存活。
Infect Immun. 1995 May;63(5):2047-53. doi: 10.1128/iai.63.5.2047-2053.1995.
Zotero 插件