艾滋病发病机制：有限的免疫反应是罪魁祸首？ - Suppr

AIDS pathogenesis: a finite immune response to blame?

作者信息

Miedema F, Klein M R

机构信息

Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.

出版信息

Science. 1996 Apr 26;272(5261):505-6. doi: 10.1126/science.272.5261.505.

DOI:10.1126/science.272.5261.505

PMID:8614796

Abstract

摘要

相似文献

AIDS pathogenesis: a finite immune response to blame?艾滋病发病机制：有限的免疫反应是罪魁祸首？

Science. 1996 Apr 26;272(5261):505-6. doi: 10.1126/science.272.5261.505.

Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection.人类免疫缺陷病毒1型在自然感染过程中的适应性进化。

Science. 1996 Apr 26;272(5261):537-42. doi: 10.1126/science.272.5261.537.

HIV-1 evolution and disease progression.HIV-1的演变与疾病进展。

Science. 1996 Nov 8;274(5289):1008-11. doi: 10.1126/science.274.5289.1008.

AIDS: decline and fall of immune surveillance?

Curr Biol. 1997 Mar 1;7(3):R136-40. doi: 10.1016/s0960-9822(97)70072-1.

Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants.

Science. 1995 Nov 24;270(5240):1360-2. doi: 10.1126/science.270.5240.1360.

AIDS. Virological mayhem.艾滋病。病毒学的混乱局面。

Nature. 1995 Jan 12;373(6510):102. doi: 10.1038/373102a0.

Plasma levels of viro-immunological markers in HIV-infected and non-infected Ethiopians: correlation with cell surface activation markers.感染和未感染艾滋病毒的埃塞俄比亚人的血浆病毒免疫标志物水平：与细胞表面活化标志物的相关性

Clin Immunol. 2001 Feb;98(2):212-9. doi: 10.1006/clim.2000.4958.

Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 T lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age.趋化因子受体CCR5基因32碱基对缺失等位基因杂合性对8岁时母婴传播感染人类免疫缺陷病毒儿童血浆病毒载量及CD4 T淋巴细胞的影响

J Infect Dis. 1998 Oct;178(4):1019-23. doi: 10.1086/515660.

A long-term follow-up of an HIV type 1-infected patient reveals a coincidence of Nef-directed cytotoxic T lymphocyte effectors and high incidence of epitope-deleted variants.一名1型艾滋病毒感染患者的长期随访显示，Nef导向的细胞毒性T淋巴细胞效应器与表位缺失变体的高发生率同时出现。

AIDS Res Hum Retroviruses. 2001 Sep 1;17(13):1265-71. doi: 10.1089/088922201750461320.

Longitudinal analysis of CD4 T cell counts, T cell reactivity, and human immunodeficiency virus type 1 RNA levels in persons remaining AIDS-free despite CD4 cell counts <200 for >5 years.对CD4细胞计数低于200且持续超过5年仍未患艾滋病的人群的CD4 T细胞计数、T细胞反应性和1型人类免疫缺陷病毒RNA水平进行纵向分析。

J Infect Dis. 1997 Sep;176(3):665-71. doi: 10.1086/514088.

引用本文的文献

Stone age diseases and modern AIDS.石器时代的疾病与现代艾滋病

Virol J. 2008 Aug 7;5:93. doi: 10.1186/1743-422X-5-93.

Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival time.早期功能性HIV特异性CD8 + T细胞的数量并不能预测无艾滋病生存时间。

PLoS One. 2008 Jul 23;3(7):e2745. doi: 10.1371/journal.pone.0002745.

CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients.CD27表达促进HIV感染患者中功能性效应记忆CD8 + 细胞毒性T淋巴细胞的长期存活。

J Exp Med. 2004 Dec 6;200(11):1407-17. doi: 10.1084/jem.20040717.

Identification of inflections in T-cell counts among HIV-1-infected individuals and relationship with progression to clinical AIDS.HIV-1感染个体T细胞计数变化的识别及其与临床艾滋病进展的关系。

Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10848-53. doi: 10.1073/pnas.95.18.10848.

Human immunodeficiency virus type 1 infection of mature CD3hiCD8+ thymocytes.1型人类免疫缺陷病毒对成熟的CD3高表达CD8阳性胸腺细胞的感染。

J Virol. 1997 Sep;71(9):6671-6. doi: 10.1128/JVI.71.9.6671-6676.1997.

Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses.来自同一传染源感染后进展为艾滋病的不同模式：1型人类免疫缺陷病毒的进化与抗病毒反应

J Virol. 1997 Jun;71(6):4284-95. doi: 10.1128/JVI.71.6.4284-4295.1997.

Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins.HIV感染中的端粒长度、端粒酶活性及复制潜能：对HIV不一致的同卵双胞胎的CD4+和CD8+ T细胞分析

J Exp Med. 1997 Apr 7;185(7):1381-6. doi: 10.1084/jem.185.7.1381.

Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro.白细胞介素-12、白细胞介素-15和白细胞介素-2对1型人类免疫缺陷病毒体外复制的不同影响。

Clin Diagn Lab Immunol. 1996 Sep;3(5):547-53. doi: 10.1128/cdli.3.5.547-553.1996.

Evaluation of an infectivity standard for real-time quality control of human immunodeficiency virus type 1 quantitative micrococulture assays. Participating Laboratories of The AIDS Clinical Trials Group.用于人类免疫缺陷病毒1型定量微培养试验实时质量控制的感染性标准评估。艾滋病临床试验组参与实验室。

J Clin Microbiol. 1996 Sep;34(9):2312-5. doi: 10.1128/jcm.34.9.2312-2315.1996.

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AIDS pathogenesis: a finite immune response to blame?

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