对CD4细胞计数低于200且持续超过5年仍未患艾滋病的人群的CD4 T细胞计数、T细胞反应性和1型人类免疫缺陷病毒RNA水平进行纵向分析。

Longitudinal analysis of CD4 T cell counts, T cell reactivity, and human immunodeficiency virus type 1 RNA levels in persons remaining AIDS-free despite CD4 cell counts <200 for >5 years.

作者信息

Keet I P, Janssen M, Veugelers P J, Miedema F, Klein M R, Goudsmit J, Coutinho R A, de Wolf F

机构信息

Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, and Department of Virology, University of Amsterdam.

出版信息

J Infect Dis. 1997 Sep;176(3):665-71. doi: 10.1086/514088.

DOI:10.1086/514088

PMID:9291313

Abstract

CD4 cell count, T cell reactivity, and human immunodeficiency virus type 1 (HIV-1) RNA load were examined in 10 persons remaining free of AIDS while CD4 cell counts were <200/mm3 for >5 years, so-called low CD4 cell count long-term survivors (low CD4 LTS), and 10 matched rapid and 10 matched intermediate progressors (AIDS within 1 and 1-3 years). Longitudinal analysis of CD4 cell count and T cell reactivity revealed slower declines in low CD4 LTS. HIV-1 RNA load was 1 log/mL lower in the low CD4 LTS compared with the rapid progressors, with a similar linear increase over time in low CD4 LTS and progressors of 0.1 log/year. There was considerable overlap between groups. The constant difference between low CD4 LTS and progressors probably reflects HIV RNA load early after infection, but low CD4 LTS and progressors show similar slopes of HIV-1 RNA load rise.

摘要

对10名在CD4细胞计数<200/mm³超过5年仍未患艾滋病的人（即所谓的低CD4细胞计数长期存活者，简称低CD4 LTS）、10名匹配的快速进展者以及10名匹配的中度进展者（分别在1年和1至3年内发展为艾滋病）进行了CD4细胞计数、T细胞反应性和1型人类免疫缺陷病毒（HIV-1）RNA载量检测。对CD4细胞计数和T细胞反应性的纵向分析显示，低CD4 LTS的下降速度较慢。与快速进展者相比，低CD4 LTS的HIV-1 RNA载量低1 log/mL，低CD4 LTS和进展者随时间的线性增加相似，均为每年0.1 log。各组之间存在相当大的重叠。低CD4 LTS和进展者之间的恒定差异可能反映了感染后早期的HIV RNA载量，但低CD4 LTS和进展者的HIV-1 RNA载量上升斜率相似。