Gebuhr P, Sletgård J, Dalsgård J, Soelberg M, Keisu K, Hänninen A, Crawford M
Department of Orthopedics, Hvidovre University Hospital, Denmark.
Acta Orthop Scand. 1996 Feb;67(1):29-32. doi: 10.3109/17453679608995604.
147 patients due to have a cemented total hip arthroplasty were randomized to 4 groups. They received either tenoxicam 20 mg or 40 mg, or placebo, for 5 days or morphine on the day of operation and placebo for 4 days. During the first 5 days 14 patients were excluded. The patients were followed for 1 year, during which another 10 patients were excluded. At follow-up, significantly fewer patients had heterotopic ossifications in the tenoxicam groups than in the placebo and morphine groups. There was no significant difference between the 2 tenoxicam-treated groups, and we therefore conclude that tenoxicam 20 mg for 5 days postoperatively can reduce heterotopic ossification after cemented total hip arthroplasty.
147例计划接受骨水泥型全髋关节置换术的患者被随机分为4组。他们分别接受20毫克或40毫克替诺昔康，或安慰剂，持续5天，或者在手术当天接受吗啡并在接下来4天接受安慰剂。在最初的5天里，有14名患者被排除。患者被随访1年，在此期间又有10名患者被排除。随访时，替诺昔康组发生异位骨化的患者明显少于安慰剂组和吗啡组。两个接受替诺昔康治疗的组之间没有显著差异，因此我们得出结论，术后5天给予20毫克替诺昔康可减少骨水泥型全髋关节置换术后的异位骨化。
