Kjaersgaard-Andersen P, Nafei A, Teichert G, Kristensen O, Schmidt S A, Keller J, Lucht U
Orthopedic Hospital, University of Aarhus, Denmark.
Acta Orthop Scand. 1993 Dec;64(6):639-42. doi: 10.3109/17453679308994587.
The effect of indomethacin 25 mg 3 times daily during the first 2 postoperative weeks in preventing heterotopic bone formation after cemented total hip arthroplasty was investigated in a randomized, double-blind and placebo-controlled clinical trial on 57 patients. 16 patients were secondarily excluded, leaving 19 patients in the indomethacin group and 22 patients in the placebo group. Evaluated from the 3-month radiographs, 18/19 indomethacin patients developed either no or only the milder Grade 1 ossification. In contrast, 11/22 placebo patients developed Grade 2 or 3 ossifications. Our observations favor indomethacin prophylaxis for 2 weeks in cemented arthroplasty of the hip.
在一项针对57例患者的随机、双盲、安慰剂对照临床试验中，研究了术后前2周每天3次服用25毫克吲哚美辛对预防骨水泥型全髋关节置换术后异位骨形成的效果。16例患者被二次排除，吲哚美辛组剩下19例患者，安慰剂组剩下22例患者。从3个月时的X光片评估，19例服用吲哚美辛的患者中18例未出现或仅出现较轻微的1级骨化。相比之下，22例安慰剂组患者中有11例出现2级或3级骨化。我们的观察结果支持在髋关节骨水泥置换术中使用吲哚美辛预防2周。
