Gertner J M, Lilburn M, Domenech M
Br Med J. 1977 May 21;1(6072):1310-2. doi: 10.1136/bmj.1.6072.1310.
Post-absorption levels of 25-hydroxy vitamin D (25-OHD) after oral administration of 25-hydroxycholecalciferol (25-OHD3) were measured in 11 subjects. Five had presented with steatorrhoea of various causes while six had post-gastrectomy osteomalacia. Post-absorption levels of 25-OHD were low in four of the patients with steatorrhoea but normal in five of those with post-gastrectomy osteomalacia. There was a significant inverse correlation between peak post-absorption 25-OHD levels and faecal fat excretion. All patients with active post-gastrectomy osteomalacia had subnormal baseline plasma 25-OHD levels, which indicates that the condition is due to a deficiency of vitamin D. Only two of the patients with osteomalacia had estimated dietary vitamin D intakes ofer 1-75 microng/day. These findings suggest that an oral 25-OHD absorption test may be a valuable measure of small intestinal function and that poor dietary vitamin D intake rather than impaired absorption of the vitamin may be the major cause of post-gastrectomy osteomalacia.
对11名受试者口服25-羟胆钙化醇（25-OHD3）后25-羟基维生素D（25-OHD）的吸收后水平进行了测量。其中5人患有各种原因引起的脂肪泻，6人患有胃切除术后骨软化症。4例脂肪泻患者的25-OHD吸收后水平较低，而6例胃切除术后骨软化症患者中有5例正常。吸收后25-OHD峰值水平与粪便脂肪排泄之间存在显著负相关。所有活动性胃切除术后骨软化症患者的基线血浆25-OHD水平均低于正常，这表明该病症是由于维生素D缺乏所致。只有2例骨软化症患者估计饮食中维生素D摄入量超过1-75微克/天。这些发现表明，口服25-OHD吸收试验可能是评估小肠功能的一项有价值的指标，饮食中维生素D摄入不足而非维生素吸收受损可能是胃切除术后骨软化症的主要原因。
