Pickett B P, Burgess L P, Livermore G H, Tzikas T L, Vossoughi J
Otolaryngology-Head and Neck Surgery Service, Walter Reed Army Medical Center, Washington, DC, USA.
Arch Otolaryngol Head Neck Surg. 1996 May;122(5):565-8. doi: 10.1001/archotol.1996.01890170097017.
To measure tensile strength of wounds closed with and without tension in rats, delineating the postoperative time interval when tensile strength is equal. To study patterns of growth in tensile strength.
Transverse incisions on the backs of control rats were closed with minimal tension. In experimental animals, after excision of skin from the back, wounds were closed with closing tensions in excess of 70 g. Animals were killed at designated healing intervals for tensile-strength testing of wounds.
One hundred Sprague-Dawley rats were divided into 5 groups days 5, 7, 10, 14, and 21, with equal numbers of control and experimental animals in each group. Wounds from 94 animals were available for breakload testing.
Closing tensions were measured for transverse incisions on the backs of control animals before closure and after removal of 50 to 60 mm of skin from the backs of experimental animals.
Tensile strength was not significantly different on day 5. However, wounds closed under tension showed significantly higher tensile strength on 7, 10, 14, 21. Polynomial regression suggests a cubic relationship between healing time and tensile strength.
Results suggest that tensile strength of wounds closed under tension exceeds that of tensionless wounds as early as day 7 following surgery. This study also illustrates the 2 periods of rapid increase in wound tensile strength that probably coincide with specific stages of wound healing.
测量大鼠有张力和无张力闭合伤口的抗张强度，确定抗张强度相等时的术后时间间隔。研究抗张强度的增长模式。
对对照大鼠背部的横向切口以最小张力闭合。在实验动物中，从背部切除皮肤后，以超过70 g的闭合张力闭合伤口。在指定的愈合间隔处死动物，对伤口进行抗张强度测试。
100只Sprague-Dawley大鼠分为5组，分别在第5、7、10、14和21天，每组中对照和实验动物数量相等。94只动物的伤口可用于断裂负荷测试。
在对照动物背部横向切口闭合前以及从实验动物背部切除50至60 mm皮肤后，测量闭合张力。
第5天时抗张强度无显著差异。然而，有张力闭合的伤口在第7、10、14、21天时抗张强度显著更高。多项式回归表明愈合时间与抗张强度之间呈三次关系。
结果表明，有张力闭合的伤口的抗张强度在术后第7天就超过了无张力伤口。本研究还说明了伤口抗张强度快速增加的两个时期，这可能与伤口愈合的特定阶段相吻合。
