Shubert P J
Department of Obstetrics and Gynecology, Ohio State University, Columbus 43210-1250, USA.
Clin Obstet Gynecol. 1995 Dec;38(4):722-4. doi: 10.1097/00003081-199538040-00007.
The role of oxytocin and oxytocin receptors in preterm labor is perhaps more prominent than once thought. The blockade of oxytocin and/or oxytocin receptors has both a theoretical and clinical aspect. Initial trials with the oxytocin antagonist atosiban have been encouraging with respect to efficacy and side effect profile. Current trials are examining the efficacy and dosing regimens of atosiban. Additional work must be done with this drug. However, if subsequent data demonstrate that atosiban is as effective as ritodrine in obtaining uterine quiescence, on the basis of its milder side effect profile, it should be seriously considered as a tocolytic of choice for the treatment of preterm labor. Moreover, it may have significant appeal for combination use with other tocolytics, given its alternative mechanism of action to betamimetics and magnesium sulfate.
缩宫素及缩宫素受体在早产中的作用可能比以往认为的更为突出。缩宫素和/或缩宫素受体的阻断具有理论和临床两方面意义。缩宫素拮抗剂阿托西班的初步试验在疗效和副作用方面都令人鼓舞。目前的试验正在研究阿托西班的疗效和给药方案。必须对这种药物开展更多研究。然而，如果后续数据表明阿托西班在使子宫安静方面与利托君一样有效，且副作用较轻，那么就应认真考虑将其作为治疗早产的首选宫缩抑制剂。此外，鉴于其与β-拟交感神经药和硫酸镁不同的作用机制，它可能对与其他宫缩抑制剂联合使用具有显著吸引力。
