Chu P, Costa J, Lachman M F
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8070, USA.
Hum Pathol. 1996 Feb;27(2):209-11. doi: 10.1016/s0046-8177(96)90379-2.
Angiotropic large cell lymphoma is reported in two patients who developed severe metabolic acidosis and unexplained hypotension before death. In addition to the usual multiorgan involvement of the disease, the adrenal glands of both patients were symmetrically enlarged. Histologically, the cortical vessels were engorged and filled with neoplastic lymphoid cells of B-cell lineage, whereas the parenchymal cells were compressed and atrophic. Angiotrophic large cell lymphoma seems to be a distinct and unrecognized cause of primary adrenal insufficiency, and should be included in the differential diagnosis of adrenal hormone deficiency.
血管趋向性大细胞淋巴瘤在两名患者中被报道，这两名患者在死亡前出现了严重的代谢性酸中毒和不明原因的低血压。除了该疾病常见的多器官受累外，两名患者的肾上腺均对称性增大。组织学上，皮质血管充血并充满B细胞系的肿瘤性淋巴细胞，而实质细胞受压且萎缩。血管趋向性大细胞淋巴瘤似乎是原发性肾上腺功能不全的一种独特且未被认识的病因，应纳入肾上腺激素缺乏的鉴别诊断中。
