Herschler R C, Olmsted A W, Edwards A J, Hale R L, Montgomery T, Preston R L, Bartle S J, Sheldon J J
Syntex Discovery Research, Palo Alto, CA 94304, USA.
J Anim Sci. 1995 Oct;73(10):2873-81. doi: 10.2527/1995.73102873x.
At each of three locations, 400 steers and an equal number of heifers were randomized to 10 treatment groups. The purpose of the studies was to evaluate the response of feedlot steers and heifers to single implants containing a combination of estradiol benzoate (EB) and trenbolone acetate (TBA) at two different ratios each at three doses. The selected ratios corresponded to 1E2(estradiol-17 beta):5TBA and 1E2:10TBA. The two ratios were each tested at three different EB/TBA doses (1:5 at 20/70, 40/140, and 60 mg/210 mg, 1:10 and 14/100, 28/200, and 42 mg/300 mg). The test groups were compared to those given each of the compounds alone (60 mg of EB or 300 mg of TBA), as well as to groups reimplanted with Synovex S or Synovex H implants and untreated controls. Steers (P < .01) and heifers (P < .05) implanted with the 1:10 E2:TBA implants gained faster and had better feed conversion (FC) than their counterparts given 1:5 E2:TBA over the 140-d trial. The results indicated that both estradiol benzoate and trenbolone acetate contributed to the efficacy of the combination implant. Contour plots of ADG and FC indicate that increasing the amount of EB above approximately 36 and 37 mg does not significantly increase the response of steers. The results of these studies indicate that the 28 EB/200 TBA dose is close to optimal for growth promotion and feed conversion in both heifers and steers. In steers, carcass value was increased (P < .01) in all test groups except the group give TBA only. Despite a slight reduction in marbling score and percentage of Choice carcasses, carcasses of steers treated with either 28 mg of EB/200 mg of TBA or 42 mg of EB/300 mg of TBA were more valuable (P < .05) than carcasses from steers in any of the 1:10 ratio EB/TBA groups. Carcass values for groups reimplanted with Synovex S or Synovex H or implanted with EB alone were not significantly different from those for groups implanted with any dose of the 1:10 EB/TBA ratio.
在三个地点,分别将400头阉牛和数量相等的小母牛随机分为10个处理组。这些研究的目的是评估育肥牛和小母牛对含有不同比例(两种比例)苯甲酸雌二醇(EB)和醋酸群勃龙(TBA)组合的单一植入剂在三种剂量下的反应。选定的比例分别为1E2(17β-雌二醇):5TBA和1E2:10TBA。这两种比例分别在三种不同的EB/TBA剂量下进行测试(1:5比例下为20/70、40/140和60毫克/210毫克,1:10比例下为14/100、28/200和42毫克/300毫克)。将测试组与单独给予每种化合物的组(60毫克EB或300毫克TBA)进行比较,同时也与重新植入Synovex S或Synovex H植入剂的组以及未处理的对照组进行比较。在为期140天的试验中,植入1:10 E2:TBA植入剂的阉牛(P <.01)和小母牛(P <.05)比植入1:5 E2:TBA的同类动物增重更快,饲料转化率(FC)更高。结果表明,苯甲酸雌二醇和醋酸群勃龙都对组合植入剂的功效有贡献。平均日增重(ADG)和饲料转化率的等高线图表明,将EB的量增加到约36毫克和37毫克以上并不会显著增加阉牛的反应。这些研究结果表明,28 EB/200 TBA剂量接近促进小母牛和阉牛生长及饲料转化的最佳剂量。在阉牛中,除了仅给予TBA的组外,所有测试组的胴体价值均有所提高(P <.01)。尽管大理石花纹评分和精选胴体百分比略有下降,但用28毫克EB/200毫克TBA或42毫克EB/300毫克TBA处理的阉牛的胴体比任何1:10比例EB/TBA组的阉牛胴体更有价值(P <.05)。重新植入Synovex S或Synovex H或仅植入EB的组的胴体价值与植入任何剂量1:10 EB/TBA比例的组的胴体价值没有显著差异。