Sano H, Tano S, Takahashi H, Terashima Y
Faculty of Animal Science, Kitasato University, Towada, Japan.
J Anim Sci. 1995 Oct;73(10):3038-43. doi: 10.2527/1995.73103038x.
n-Butyrate (0, 1, 2, 4, 8, 16, 32, and 64 mumol.kg BW-1.min-1) was infused i.v. for 30 min to investigate the physiological effects of n-butyrate on plasma insulin and glucagon responses in sheep. Blood n-butyrate concentrations during n-butyrate infusion increased (P < .01) with increasing infusion rates. At the greater infusion rates of n-butyrate, plasma glucose concentrations increased (P < .01) during infusion, and then they decreased (P < .05) to less than the preinfusion values. Plasma insulin concentrations increased (P < .01) dose-dependently during n-butyrate infusion at rates of > or = 2 mumol.kg BW-1.min-1. Plasma glucagon concentrations increased (P < .05) during n-butyrate infusion at rates of 32 and 64 mumol.kg BW-1.min-1. It is possible that, in sheep, n-butyrate may have a physiological role in controlling insulin secretion; however, it does not seem to have a role in glucagon secretion.
静脉注射不同剂量的正丁酸盐（0、1、2、4、8、16、32和64微摩尔·千克体重⁻¹·分钟⁻¹）30分钟，以研究正丁酸盐对绵羊血浆胰岛素和胰高血糖素反应的生理作用。随着正丁酸盐输注速率的增加，输注期间血液中正丁酸盐浓度升高（P < 0.01）。在较高的正丁酸盐输注速率下，输注期间血浆葡萄糖浓度升高（P < 0.01），然后下降（P < 0.05）至低于输注前值。当正丁酸盐输注速率≥2微摩尔·千克体重⁻¹·分钟⁻¹时，血浆胰岛素浓度呈剂量依赖性增加（P < 0.01）。当正丁酸盐输注速率为32和64微摩尔·千克体重⁻¹·分钟⁻¹时，血浆胰高血糖素浓度升高（P < 0.05）。在绵羊中，正丁酸盐可能在控制胰岛素分泌方面具有生理作用；然而，它似乎在胰高血糖素分泌中不起作用。
