Sano H, Hayakawa S, Takahashi H, Terashima Y
Faculty of Animal Science, Kitasato University, Towada-shi, Japan.
J Anim Sci. 1995 Jan;73(1):191-7. doi: 10.2527/1995.731191x.
Propionate (1, 2, 4, 8, 16, 32, and 64 mumol.kg BW-1.min-1 for 30 min) was infused into the femoral and mesenteric veins of adult sheep to investigate the physiological significance of propionate in regulating plasma insulin and glucagon concentrations. The increments in arterial blood propionate concentrations during propionate infusion increased (P < .001) with increasing infusion rates for both infusion sites, and they were smaller (P < .001) for the mesenteric vein infusion than for the femoral vein infusion. Plasma insulin concentrations during propionate infusion increased (P < .10) from preinfusion values with infusion rates of > or = 8 mumol.kg BW-1.min-1 for both infusion sites. The response areas of plasma insulin concentration above basal tended to be smaller (P < .112) for the mesenteric vein infusion than for the femoral vein infusion. Plasma glucagon concentrations during propionate infusion increased (P < .05) from preinfusion values with infusion rates of > or = 8 and 64 mumol.kg BW-1.min-1 for the femoral and mesenteric vein infusions, respectively. The response areas of plasma glucagon concentration above basal were smaller (P < .011) for the mesenteric vein infusion than for the femoral vein infusion. We conclude that in sheep propionate absorbed from the alimentary tract has a physiological role in regulating circulating concentrations of insulin and glucagon.
将丙酸盐（1、2、4、8、16、32和64 μmol·kg体重⁻¹·min⁻¹，持续30分钟）注入成年绵羊的股静脉和肠系膜静脉，以研究丙酸盐在调节血浆胰岛素和胰高血糖素浓度方面的生理意义。在两个注入部位，随着注入速率的增加，丙酸盐注入期间动脉血丙酸盐浓度的增量均增加（P <.001），并且肠系膜静脉注入时的增量小于股静脉注入时的增量（P <.001）。在两个注入部位，当注入速率≥8 μmol·kg体重⁻¹·min⁻¹时，丙酸盐注入期间的血浆胰岛素浓度较注入前值升高（P <.10）。肠系膜静脉注入时，血浆胰岛素浓度高于基础值的反应面积往往小于股静脉注入时（P <.112）。在丙酸盐注入期间，当股静脉和肠系膜静脉的注入速率分别≥8和64 μmol·kg体重⁻¹·min⁻¹时，血浆胰高血糖素浓度较注入前值升高（P <.05）。肠系膜静脉注入时，血浆胰高血糖素浓度高于基础值的反应面积小于股静脉注入时（P <.011）。我们得出结论，在绵羊中，从消化道吸收的丙酸盐在调节胰岛素和胰高血糖素的循环浓度方面具有生理作用。
