Malaviya R, Morrison A R, Pentland A P
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
J Invest Dermatol. 1996 Apr;106(4):785-9. doi: 10.1111/1523-1747.ep12346356.
Human epidermal cell cultures were examined to determine whether they were capable of histamine release. Results of these studies indicated that keratinocytes contain and release significant amounts of histamine. In the skin of some individuals, histamine content was induced after ultraviolet B light injury, and 40% of subjects demonstrated high basal histamine levels. Mass spectrometric analysis of cell supernatants showed that the histamine was released into the extracellular environment. Such release may contribute to common itching or intensify the inflammatory response in vivo.
对人表皮细胞培养物进行检测，以确定它们是否能够释放组胺。这些研究结果表明，角质形成细胞含有并释放大量组胺。在一些个体的皮肤中，紫外线B光损伤后组胺含量会升高，40%的受试者表现出较高的基础组胺水平。对细胞上清液的质谱分析表明，组胺被释放到细胞外环境中。这种释放可能导致常见的瘙痒或加剧体内的炎症反应。
