唐氏综合征中乳糜泻的高发病率。
High frequency of celiac disease in Down syndrome.
作者信息
George E K, Mearin M L, Bouquet J, von Blomberg B M, Stapel S O, van Elburg R M, de Graaf E A
机构信息
Department of Pediatrics, University Hospital Leiden, The Netherlands.
出版信息
J Pediatr. 1996 Apr;128(4):555-7. doi: 10.1016/s0022-3476(96)70369-4.
PMID:8618192
Abstract
We screened 115 children with Down syndrome for celiac disease, using antigliadin, antiendomysium, and antireticulin serum antibodies and an intestinal permeability test. Celiac disease was diagnosed in eight children, giving a frequency of 7.0%. We recommend screening for celiac disease in all persons with Down syndrome, with the use of at least the antiendomysium antibody determination.
摘要
我们使用抗麦醇溶蛋白、抗肌内膜和抗网硬蛋白血清抗体以及肠道通透性试验，对115名唐氏综合征患儿进行了乳糜泻筛查。8名儿童被诊断为乳糜泻，发病率为7.0%。我们建议对所有唐氏综合征患者进行乳糜泻筛查，至少采用抗肌内膜抗体检测法。
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