Van den Berg L, Hays A P, Nobile-Orazio E, Kinsella L J, Manfredini E, Corbo M, Rosoklija G, Younger D S, Lovelace R E, Trojaborg W, Lange D E, Goldstein S, Delfiner J S, Sadiq S A, Sherman W H, Latov N
Department of Neurology, Columbia Presbyterian Medical Center, New York, USA.
Muscle Nerve. 1996 May;19(5):637-43. doi: 10.1002/(SICI)1097-4598(199605)19:5<637::AID-MUS12>3.0.CO;2-K.
We compared the binding of human antibodies from patients with neuropathy to the myelin-associated glycoprotein (MAG), to its cross-reactive glycolipid sulfoglucuronyl paragloboside (SGPG), and to sections of peripheral nerve. Titers were correlated with the clinical presentation and results of electrophysiological and pathological studies. Most patients had a predominantly sensory or sensorimotor demyelinating neuropathy and highly elevated antibodies to both MAG and SGPG, but 2 had highly elevated antibodies to MAG alone, and 1 to SGPG alone. Two patients had predominantly motor neuropathy and highly elevated antibodies to SGPG which reacted with MAG by Western blot but not by enzyme-linked immunosorbent assay. One patient had amyotrophic lateral sclerosis and antibodies to SGPG but not to MAG. These studies indicate that the neuropathic syndrome associated with anti-MAG or -SGPG antibodies are more heterogeneous than previously suspected, and that although most of the antibodies react with both MAG and SGPG, some may react with MAG or SGPG alone.
我们比较了患有神经病变的患者体内的人源抗体与髓鞘相关糖蛋白（MAG）、其交叉反应性糖脂硫代葡萄糖醛酸副球蛋白（SGPG）以及周围神经切片的结合情况。抗体滴度与临床表现以及电生理和病理研究结果相关。大多数患者主要表现为感觉性或感觉运动性脱髓鞘性神经病变，且针对MAG和SGPG的抗体水平均显著升高，但有2例患者仅针对MAG的抗体水平显著升高，1例患者仅针对SGPG的抗体水平显著升高。2例患者主要表现为运动性神经病变，针对SGPG的抗体水平显著升高，通过蛋白质印迹法检测其与MAG发生反应，但酶联免疫吸附测定法检测无反应。1例患者患有肌萎缩侧索硬化症，其体内有针对SGPG而非MAG的抗体。这些研究表明，与抗MAG或抗SGPG抗体相关的神经病变综合征比之前怀疑的更加异质性，并且尽管大多数抗体与MAG和SGPG均发生反应，但有些抗体可能仅与MAG或SGPG发生反应。
