Mori Y, Yamanishi K
Department of Microbiology, Osaka University Medical School.
Nihon Rinsho. 1998 Jan;56(1):17-21.
HHV-6 was first isolated in 1986 from patients with lymphoproliferative disorders and was classified into 2 variants such as HHV-6A and HHV-6B. It was reported that HHV-6B is the causative agent of exanthem subitum (ES). Children start to be infected with HHV-6 at 6 month of age and almost all get antibody by 2 years old. HHV-6 infects latently after the primary infection and reactivates especially under the immunosuppressive condition. HHV-7 was first isolated in 1990 and the HHV-7 infection occurs later than HHV-6. Children get HHV-7 infection mostly inapparently, but HHV-7 also cause ES. Since HHV-6 has several genes which transactivate long terminal repeat (LTR) of HIV, it is proposed that HHV-6 may have a role as the cofactor for AIDS.
人疱疹病毒6型于1986年首次从患有淋巴增生性疾病的患者中分离出来，并被分为HHV-6A和HHV-6B两种变体。据报道，HHV-6B是幼儿急疹（ES）的病原体。儿童在6个月大时开始感染HHV-6，几乎所有儿童在2岁时都会产生抗体。HHV-6在初次感染后潜伏感染，尤其在免疫抑制条件下会重新激活。人疱疹病毒7型于1990年首次分离出来，HHV-7感染比HHV-6出现得晚。儿童大多隐性感染HHV-7，但HHV-7也会引起幼儿急疹。由于HHV-6有几个基因可反式激活HIV的长末端重复序列（LTR），因此有人提出HHV-6可能作为艾滋病的辅助因子发挥作用。
