Laakso M P, Partanen K, Riekkinen P, Lehtovirta M, Helkala E L, Hallikainen M, Hanninen T, Vainio P, Soininen H
Department of Neurology, University of Kuopio, Finland.
Neurology. 1996 Mar;46(3):678-81. doi: 10.1212/wnl.46.3.678.
Hippocampal atrophy detected by volumetric MRI is a sensitive feature of early Alzheimer's disease (AD), but there are no studies evaluating hippocampal atrophy by MR volumetry in other dementing diseases. We therefore compared hippocampal volumes in a total of 113 subjects: 50 patients with mild to moderate AD, 9 patients with vascular dementia (VaD), 12 patients with idiopathic Parkinson's disease (PD) without dementia, 8 patients with PD and dementia (PDD), and 34 elderly control subjects. Thin, coronal, contiguous images were obtained by a 1.5-T MR imager. All patient groups had significantly smaller volumes of the hippocampus compared with the control group. In the PDD group, the absolute volumes were even smaller than in the AD group. In the PD group, the volumes were diminished to a lesser but significant extent. The volumes in the VaD group varied: of nine patients, two had no atrophy, three had unilateral, and four had bilateral atrophy. We postulate that hippocampal atrophy does not seem to be a specific phenomenon of dementia in AD but also occurs in VaD and PDD, and even in PD when no dementia is present. However, coexistence of AD pathology in our PD and VaD patients cannot be ruled out. Further studies with access to neuropathologic data are needed.
通过容积磁共振成像（MRI）检测到的海马萎缩是早期阿尔茨海默病（AD）的一个敏感特征，但尚无研究通过磁共振容积测量法评估其他痴呆疾病中的海马萎缩情况。因此，我们比较了总共113名受试者的海马体积：50例轻度至中度AD患者、9例血管性痴呆（VaD）患者、12例无痴呆的特发性帕金森病（PD）患者、8例伴有痴呆的PD（PDD）患者以及34名老年对照受试者。通过1.5-T磁共振成像仪获取薄层冠状连续图像。与对照组相比，所有患者组的海马体积均显著减小。在PDD组中，绝对体积甚至比AD组更小。在PD组中，体积减小程度较小但具有显著性。VaD组的体积各不相同：9例患者中，2例无萎缩，3例单侧萎缩，4例双侧萎缩。我们推测，海马萎缩似乎并非AD痴呆的特异性现象，在VaD和PDD中也会出现，甚至在无痴呆的PD中也会出现。然而，不能排除我们的PD和VaD患者中存在AD病理共存的情况。需要进一步获取神经病理学数据的研究。
