Peters M A, van Sluijs F J
Faculteit der Diergeneeskunde, Vakgroep Geneeskunde van Gezelschapsdieren, Universiteit Utrecht.
Tijdschr Diergeneeskd. 1996 Jan 15;121(2):36-8.
The incidence of testicular tumours in dogs is higher than in other species. The main three types are: Sertoli cell tumour, seminoma, and Leydig cell tumour. Metastases are rare. Sertoli cell tumours, and to a lesser extent Leydig cell tumours, are often associated with feminization, which occurs in 19% and 5% of cases, respectively. Seminomas are rarely associated with feminization. Feminization seems to be the result of an excessive oestrogen production by the tumour. In severe cases this may lead to bone marrow depression. Atrophy of the contralateral testis is a common finding. It is not clear whether this is a result of feminization or of age because most tumours occur in older dogs. By investigating the morphology of the testis, and the endocrinological and fertility status of the dog this phenomena is hopefully going to be explained. Extra attention is given to the pathogenesis of feminization.
犬睾丸肿瘤的发病率高于其他物种。主要的三种类型是:支持细胞瘤、精原细胞瘤和间质细胞瘤。转移很少见。支持细胞瘤,以及程度较轻的间质细胞瘤,常与雌性化有关,分别发生在19%和5%的病例中。精原细胞瘤很少与雌性化有关。雌性化似乎是肿瘤过度产生雌激素的结果。在严重情况下,这可能导致骨髓抑制。对侧睾丸萎缩是常见现象。目前尚不清楚这是雌性化还是年龄的结果,因为大多数肿瘤发生在老年犬身上。通过研究睾丸的形态、犬的内分泌和生育状况,有望解释这一现象。对雌性化的发病机制给予了特别关注。