Sherding R G, Wilson G P, Kociba G J
J Am Vet Med Assoc. 1981 Mar 1;178(5):497-501.
Eight male dogs with Sertoli cell tumor had pancytopenia and bone marrow hypoplasia attributed to endogenous estrogen myelotoxicosis. Clinical signs were hemorrhage caused by thrombocytopenia, anemia caused by blood loss or diminished erythrocyte production, and infection and fever associated with granulocytopenia. Other signs attributed to hyperestrogenism were feminization and prostatic disease. Two dogs recovered after castration and supportive treatment, but 5 other similarly treated dogs died of hematopoietic failure. One dog was euthanatized.
八只患有支持细胞瘤的雄性犬出现全血细胞减少和骨髓发育不全，归因于内源性雌激素骨髓毒性。临床症状包括血小板减少引起的出血、失血或红细胞生成减少引起的贫血，以及与粒细胞减少相关的感染和发热。其他归因于雌激素过多的症状包括雌性化和前列腺疾病。两只犬在去势和支持性治疗后康复，但另外五只接受类似治疗的犬死于造血功能衰竭。一只犬被安乐死。
