9-β-D-阿拉伯呋喃糖基腺嘌呤与2'-脱氧助间型霉素联合用药对脑内白血病的治疗作用
Therapeutic effects of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin combinations on intracerebral leukemia.
作者信息
Lee S H, Caron N, Kimball A P
出版信息
Cancer Res. 1977 Jul;37(7 Pt 1):1953-5.
PMID:861931
Abstract
Drug combinations of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin were active in the therapy of mice with intracerebral implants of the L1210 tumor. In in vivo mouse brain adenosine deaminase studies, inhibition of 9-beta-D-arabinofuranosyladenine deamination for periods of up to 24 hr was found after a single i.p. dose of 0.002 mmole/kg.
摘要
9-β-D-阿拉伯呋喃糖基腺嘌呤与2'-脱氧助间型霉素的药物组合对脑内植入L1210肿瘤的小鼠治疗有效。在体内小鼠脑腺苷脱氨酶研究中，腹腔注射单次剂量0.002毫摩尔/千克后，发现9-β-D-阿拉伯呋喃糖基腺嘌呤脱氨抑制长达24小时。
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