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9-β-D-阿拉伯呋喃糖基腺嘌呤与2'-脱氧助间型霉素联合用药对脑内白血病的治疗作用

Therapeutic effects of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin combinations on intracerebral leukemia.

作者信息

Lee S H, Caron N, Kimball A P

出版信息

Cancer Res. 1977 Jul;37(7 Pt 1):1953-5.

PMID:861931
Abstract

Drug combinations of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin were active in the therapy of mice with intracerebral implants of the L1210 tumor. In in vivo mouse brain adenosine deaminase studies, inhibition of 9-beta-D-arabinofuranosyladenine deamination for periods of up to 24 hr was found after a single i.p. dose of 0.002 mmole/kg.

摘要

9-β-D-阿拉伯呋喃糖基腺嘌呤与2'-脱氧助间型霉素的药物组合对脑内植入L1210肿瘤的小鼠治疗有效。在体内小鼠脑腺苷脱氨酶研究中，腹腔注射单次剂量0.002毫摩尔/千克后，发现9-β-D-阿拉伯呋喃糖基腺嘌呤脱氨抑制长达24小时。

相似文献

1
Therapeutic effects of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin combinations on intracerebral leukemia.9-β-D-阿拉伯呋喃糖基腺嘌呤与2'-脱氧助间型霉素联合用药对脑内白血病的治疗作用
Cancer Res. 1977 Jul;37(7 Pt 1):1953-5.
2
Effects of 2'-deoxycoformycin, 9-beta-D-arabinofuranosyladenine 5'-phosphate, and 1-beta-D-arabinofuranosylcytosine triple combination therapy on intracerebral leukemia 1210.2'-脱氧助间型霉素、9-β-D-阿拉伯呋喃糖基腺嘌呤5'-磷酸酯和1-β-D-阿拉伯呋喃糖基胞嘧啶三联联合疗法对脑内白血病1210的影响
Cancer Res. 1977 Sep;37(9):3274-9.
3
Enhancement of 9-beta-d-arabinofuranosyladenine cytotoxicity to mouse leukemia L1210 in vitro by 2'-deoxycoformycin.2'-脱氧助间型霉素增强9-β-D-阿拉伯呋喃糖基腺嘌呤对小鼠白血病L1210细胞的体外细胞毒性。
Cancer Res. 1976 Apr;36(4):1486-91.
4
Enhancement of the antitumor activity of arabinofuranosyladenine of 2'-deoxycoformycin.2'-脱氧助间型霉素增强阿糖呋喃腺嘌呤的抗肿瘤活性。
Cancer Res. 1976 Apr;36(4):1481-5.
5
Antiproliferative effects of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and related compounds in combination with adenosine deaminase inhibitors against mouse leukemia L1210/C2 cells in culture.9-β-D-阿拉伯呋喃糖基腺嘌呤5'-单磷酸及其相关化合物与腺苷脱氨酶抑制剂联合对培养的小鼠白血病L1210/C2细胞的抗增殖作用。
Cancer Res. 1979 May;39(5):1563-9.
6
Effects of 2'-deoxycoformycin and erythro-9-(2-hydroxy-3-nornyl)adenine on plasma levels and urinary excretion of 9-beta-D-arabinofuranosyladenine in the mouse 1,2,3.
Cancer Treat Rep. 1978 Mar;62(3):369-73.
7
Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo.体内2'-脱氧助间型霉素抑制的小鼠红细胞和白血病L1210腺苷脱氨酶的恢复
Cancer Res. 1979 Apr;39(4):1425-7.
8
Two approaches that increase the activity of analogs of adenine nucleosides in animal cells.两种提高腺嘌呤核苷类似物在动物细胞中活性的方法。
Cancer Res. 1975 Jun;35(6):1547-54.
9
Biochemical basis of the increased activity of 9-beta-D-arabinofuranosyladenine in the presence of inhibitors of adenosine deaminase.腺苷脱氨酶抑制剂存在时9-β-D-阿拉伯呋喃糖基腺嘌呤活性增加的生化基础
Cancer Res. 1979 Sep;39(9):3655-60.
10
Inhibition of drug metabolism by a prodrug: 9-beta-D-arabinofuranosyladenine 5'-valerate as an inhibitor of adenosine deaminase.
Mol Pharmacol. 1978 Mar;14(2):366-9.

引用本文的文献

1
Adenosine deaminase inhibitors: their role in chemotherapy and immunosuppression.腺苷脱氨酶抑制剂：它们在化疗和免疫抑制中的作用。
Cancer Chemother Pharmacol. 1980;4(4):227-35. doi: 10.1007/BF00255266.
2
Physiologic model for the pharmacokinetics of 2'deoxycoformycin in normal and leukemic mice.
J Pharmacokinet Biopharm. 1981 Oct;9(5):519-34. doi: 10.1007/BF01061024.