Ozawa K, Nakagomi K, Yonese J, Kojima S, Tsuzii T, Satake I, Tari K, Sakura M, Kato S, Kazumoto T
Deparment of Urology, Saitama Cancer Center, Japan.
Hinyokika Kiyo. 1996 Mar;42(3):191-5.
From 1981 to 1994, intra-operative radiotherapy after subtotal cystectomy was performed on 22 patients with invasive bladder carcinoma on whom radical cystectomy could not be recommended because of old age or condition. All the patients received 25 to 30 Gy of radiotherapy focused on trigonum and internal urethral orifice after subtotal cystectomy with uretero-cutaneostomy. Of 22 patients, 15 patients died. Five patients died of bladder cancer, one died of gastric cancer, one died of rectal cancer and the others died of pneumonia, heart failure, sepsis and senility. The five-year survival rate was 41% and the cause-specific five-year survival rate was 75%. Local recurrence was seen only in one patients, who received second intra-operative radiotherapy and recovered well in complete remission. We believe that intra-operative radiotherapy after subtotal cystectomy is useful for patients with invasive bladder carcinoma on whom radical cystectomy could not be recommended because of old age or condition.
1981年至1994年，对22例因年龄或身体状况而不适合行根治性膀胱切除术的浸润性膀胱癌患者进行了膀胱部分切除术后术中放疗。所有患者在膀胱部分切除并输尿管皮肤造口术后接受了25至30 Gy聚焦于三角区和尿道内口的放疗。22例患者中，15例死亡。5例死于膀胱癌，1例死于胃癌，1例死于直肠癌，其他死于肺炎、心力衰竭、败血症和衰老。五年生存率为41%，病因特异性五年生存率为75%。仅1例出现局部复发，该患者接受了第二次术中放疗，完全缓解且恢复良好。我们认为，对于因年龄或身体状况而不适合行根治性膀胱切除术的浸润性膀胱癌患者，膀胱部分切除术后术中放疗是有效的。
