Gewirtz A S, Miller M L, Keys T F
Department of Clinical Pathology, The Cleveland Clinic Foundation, Ohio 44195, USA.
Arch Pathol Lab Med. 1996 Apr;120(4):353-6.
To determine the clinical utilization of the Simplate bleeding time test as a preoperative screen, to examine the clinical utilization of the bleeding time test by multiple surgical services, and to correlate the indicators of bleeding risk (bleeding history, thrombocytopenia, prolonged prothrombin time/activated partial thromboplastin time, increased creatinine, and medications known to interfere with platelet function) with the bleeding time and the occurrence of clinically significant perioperative bleeding.
Retrospective data analysis.
A large tertiary-care hospital.
One hundred sixty-seven consecutive surgical patients tested for preoperative bleeding time.
The occurrence of clinically significant perioperative bleeding and the positive and negative predictive value of the preoperative screening bleeding time test.
Patients with a positive bleeding history were more likely to have an abnormal bleeding time (P = .04), but there was no statistically significant association between patients with an abnormal bleeding time and the other indicators of bleeding risk examined or the occurrence of clinically significant perioperative bleeding. The positive predictive value of the preoperative bleeding time was 5%, and the negative predictive value was 95%.
Screening for preoperative bleeding time is not a reliable test for assessing the risk of clinically significant perioperative bleeding and should not be used for this purpose.
确定Simplate出血时间测试作为术前筛查的临床应用情况,研究多个外科科室对出血时间测试的临床应用情况,并将出血风险指标(出血史、血小板减少症、凝血酶原时间/活化部分凝血活酶时间延长、肌酐升高以及已知会干扰血小板功能的药物)与出血时间及具有临床意义的围手术期出血的发生情况进行关联分析。
回顾性数据分析。
一家大型三级医疗中心。
167例连续接受术前出血时间检测的外科手术患者。
具有临床意义的围手术期出血的发生情况以及术前筛查出血时间测试的阳性和阴性预测值。
有出血史阳性的患者更有可能出现出血时间异常(P = 0.04),但出血时间异常的患者与所检测的其他出血风险指标或具有临床意义的围手术期出血的发生之间,无统计学显著关联。术前出血时间的阳性预测值为5%,阴性预测值为95%。
术前出血时间筛查并非评估具有临床意义的围手术期出血风险的可靠测试,不应为此目的而使用。