Viciana M J, Galera-Davidson H, Martín-Lacave I, Segura D I, Loizaga J M
Department of Pathology, "Virgen Macarena" Hospital, Seville, Spain.
Arch Pathol Lab Med. 1996 Apr;120(4):397-8.
A case of papillary carcinoma of the thyroid with mucoepidermoid differentiation is reported. There have been different hypotheses of the histogenesis of this tumor, one of which attributes the origin of the tumor to the ultimobranchial body, mainly because of the presence of neuroendocrine markers. In our case, no neuroendocrine immunohistochemical markers were demonstrated, but a progressive transition between follicular cells and mucinous cells with gradual loss of thyroglobulin immunoreactivity and acquisition of polyclonal carcinoembryonic antigen reactivity was noted. Therefore, we propose that mucoepidermoid carcinoma may be a simple metaplastic transformation of a papillary carcinoma, because the thyroid glandular epithelium, which is of endodermal origin, is capable of differentiating easily into squamous, mucus-secreting, or even polypeptide-secreting epithelium.
报告了1例伴有黏液表皮样分化的甲状腺乳头状癌病例。关于该肿瘤的组织发生学存在不同假说，其中之一将肿瘤起源归因于最后鳃体，主要是因为存在神经内分泌标志物。在我们的病例中，未显示神经内分泌免疫组化标志物，但注意到滤泡细胞与黏液细胞之间存在渐进性转变，同时甲状腺球蛋白免疫反应性逐渐丧失，多克隆癌胚抗原反应性增加。因此，我们提出黏液表皮样癌可能是乳头状癌的一种单纯化生转变，因为起源于内胚层的甲状腺腺上皮能够轻易分化为鳞状、分泌黏液甚至分泌多肽的上皮。
