Kasravi F B, Adawi D, Molin G, Bengmark S, Jeppsson B
Department of Surgery, Lund University, Sweden.
APMIS. 1996 Feb;104(2):135-40. doi: 10.1111/j.1699-0463.1996.tb00698.x.
Bacterial translocation may play a role in acute liver injuries as high rates of infectious and septic complications are observed in these clinical conditions. Increased passage of endotoxin and translocating bacteria not only potentiates the extent of liver injury, but may also play a determining role in its final outcome. In this paper the incidence of bacteria] translocation in acute liver injury in rats is evaluated with other important pathological changes observed at different time points after liver injury induced by intraperitoneal administration of D-galactosamine. The bacterial translocation to the blood and other extraintestinal sites starts 3 h after induction of liver injury and is not found to be related to light microscopic changes in the liver or ileal or cecal mucosa, detectable levels of endotoxin in the portal blood, or DNA changes in the small and large intestinal mucosa, but corresponds to the release of liver enzymes in the serum.
细菌移位可能在急性肝损伤中起作用，因为在这些临床情况下观察到感染性和脓毒症并发症的发生率很高。内毒素和移位细菌的通过增加不仅会增强肝损伤的程度，还可能在其最终结果中起决定性作用。本文通过腹腔注射D-半乳糖胺诱导大鼠肝损伤后不同时间点观察到的其他重要病理变化，评估了大鼠急性肝损伤中细菌移位的发生率。肝损伤诱导后3小时开始出现细菌向血液和其他肠外部位的移位，且发现其与肝脏、回肠或盲肠黏膜的光镜变化、门静脉血中可检测到的内毒素水平或小肠和大肠黏膜中的DNA变化无关，但与血清中肝酶的释放相对应。
