Fujikawa Y, Shingu M, Torisu T, Itonaga I, Masumi S
Department of Orthopaedic Surgery, Oita Medical University, Japan.
Br J Rheumatol. 1996 Mar;35(3):213-7. doi: 10.1093/rheumatology/35.3.213.
Inflammatory reactions in rheumatoid arthritis (RA) often cause severe joint destruction. However, the mechanism of bone destruction is still a matter of controversy. To determine whether multinuclear cells found in the rheumatoid synovium can resorb bone, isolated synovial cells were assessed for tartrate-resistant acid phosphatase (TRAP) staining and the ability to resorb bone in a dentine resorption assay. TRAP-positive multinuclear cells were found in six out of 10 samples. These six samples showed resorption pit formation on dentine slices. The other four samples did not form resorption pits. The results of this study demonstrate that TRAP-positive multinuclear cells isolated from the rheumatoid synovium form resorption pits on dentine slices. Our results suggest that inflamed synovial cells in rheumatoid joints might participate in bone destruction.
类风湿关节炎（RA）中的炎症反应常导致严重的关节破坏。然而，骨破坏的机制仍存在争议。为了确定在类风湿滑膜中发现的多核细胞是否能吸收骨质，对分离出的滑膜细胞进行了抗酒石酸酸性磷酸酶（TRAP）染色评估，并在牙本质吸收试验中检测其吸收骨质的能力。在10个样本中的6个样本中发现了TRAP阳性多核细胞。这6个样本在牙本质切片上出现了吸收凹坑形成。另外4个样本未形成吸收凹坑。本研究结果表明，从类风湿滑膜中分离出的TRAP阳性多核细胞在牙本质切片上形成吸收凹坑。我们的结果提示，类风湿关节中发炎的滑膜细胞可能参与骨破坏。
