Chang J S, Quinn J M, Demaziere A, Bulstrode C J, Francis M J, Duthie R B, Athanasou N A
Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Oxford, United Kingdom.
Ann Rheum Dis. 1992 Nov;51(11):1223-9. doi: 10.1136/ard.51.11.1223.
Cellular mechanisms accounting for the osteolysis of rheumatoid erosions are poorly understood. Cells were isolated and characterised from the synovium of 16 patients with rheumatoid arthritis (RA) and four patients with osteoarthritis and their ability to resorb bone was assessed using a scanning electron microscope bone resorption assay. Macrophages were the major cell type isolated from the synovium of patients with RA. These produced extensive roughening of the bone surface without resorption pit formation. This low grade type of bone resorption was not affected by systemic (calcitonin, parathyroid hormone, 1,25-dihydroxyvitamin D3) or local (interleukin 1, prostaglandin E2) factors influencing bone resorption. Macrophage mediated bone resorption differs qualitatively and quantitatively from that of osteoclasts but is likely to play an important part in the development of marginal erosions in RA.
导致类风湿性侵蚀骨溶解的细胞机制尚不清楚。从16例类风湿关节炎（RA）患者和4例骨关节炎患者的滑膜中分离并鉴定细胞，并使用扫描电子显微镜骨吸收试验评估其骨吸收能力。巨噬细胞是从RA患者滑膜中分离出的主要细胞类型。这些细胞使骨表面广泛粗糙，但未形成吸收陷窝。这种低级别类型的骨吸收不受影响骨吸收的全身因素（降钙素、甲状旁腺激素、1,25 - 二羟基维生素D3）或局部因素（白细胞介素1、前列腺素E2）的影响。巨噬细胞介导的骨吸收在质量和数量上与破骨细胞不同，但可能在RA边缘侵蚀的发展中起重要作用。
