Kassa J, Bajgar J
Vojenská lékarská akademie JEP, Hradec Králové.
Ceska Slov Farm. 1996 Feb;45(1):31-4.
In experiments on male mice, the effect of the cholinesterase reactivators obidoxime, methoxime and HI-6 in combination with atropine sulfate on the acute intoxication with the organophosphorous insecticide fosdrine was tested in dependence on the period of administration of drugs after intoxication and on the dose of oxime by influencing the LD50 value in 48-hour survival of experimental animals. It has been demonstrated that the rate of the therapeutic intervention is a much more important factor influencing the effect of oximes than the dose of oximes. A shortening of the period of drug administration from 2 minutes to 30 seconds substantially increases the effects of all three oximes. A comparison of the effects of all three reactivators has shown that the oxime HI-6 is significantly more effective than the remaining two reactivators in the case of therapy of intoxication 30 seconds after the application of the noxa. In the therapy of intoxication 2 minutes after the exposure of experimental animals to fosdrine, the effect of the antidotal therapy was relatively low regardless of the selected oxime.
在雄性小鼠实验中，研究了胆碱酯酶复活剂双复磷、甲氧肟和HI-6与硫酸阿托品联合使用，对有机磷杀虫剂硫丹急性中毒的影响，该影响取决于中毒后药物的给药时间以及肟的剂量，通过影响实验动物48小时存活的半数致死量（LD50）值来进行研究。结果表明，治疗干预的时机比肟的剂量是影响肟类药物效果的更重要因素。将给药时间从2分钟缩短至30秒可显著增强所有三种肟的效果。对所有三种复活剂效果的比较表明，在接触有毒物质30秒后进行中毒治疗时，肟HI-6比其余两种复活剂显著更有效。在实验动物接触硫丹2分钟后进行中毒治疗时，无论选择哪种肟，解毒治疗的效果都相对较低。
