Bentdal O H, Frøland S S, Bosnes V, Bergan A, Søreide O, Flatmark A
Department of Surgery, Rikshospitalet, The National Hospital, University of Oslo, Norway.
Cancer Lett. 1996 Feb 27;100(1-2):133-8. doi: 10.1016/0304-3835(95)04080-3.
Impaired immune responses in patients with carcinoma of cardia or oesophagus have previously been reported. However, we do not know whether resectability correlates with specific immunological variables. Immunological assessment was performed in 35 such cancer patients including measurement of total T cells (CD3+) and T cell subsets (CD4+ and CD8+), NK cells (CD16+) and B cells (CD19+) in blood. In vitro lymphocyte responses to phytohemagglutinin (PHA) separated from peripheral blood were quantitated. The numbers in peripheral blood of both total T cells (CD3+) and B lymphocytes (CD19+) were significantly lower in the inoperable patients compared to resected patients (P < 0.01). The number of NK cells (CD16+) was, however, not significantly lower in the inoperable patients compared to the patients operated for cure. Lymphocyte responses to PHA in vitro were similar in resectable and non-resectable patients, but significantly lower in inoperable patients compared to the controls (P < 0.01). In conclusion, resectability in carcinoma of cardia or oesophagus is associated with changes in both T (CD3+) and B (CD19+) cell subsets.
先前已有报道称贲门癌或食管癌患者存在免疫反应受损的情况。然而，我们并不清楚可切除性是否与特定的免疫变量相关。对35例此类癌症患者进行了免疫评估，包括测定血液中的总T细胞（CD3 +）和T细胞亚群（CD4 +和CD8 +）、自然杀伤细胞（CD16 +）和B细胞（CD19 +）。对从外周血中分离出的淋巴细胞对植物血凝素（PHA）的反应进行了定量分析。与可切除患者相比，不可切除患者外周血中的总T细胞（CD3 +）和B淋巴细胞（CD19 +）数量显著更低（P < 0.01）。然而，与接受根治性手术的患者相比，不可切除患者的自然杀伤细胞（CD16 +）数量并无显著降低。可切除和不可切除患者的淋巴细胞对PHA的体外反应相似，但与对照组相比，不可切除患者的反应显著更低（P < 0.01）。总之，贲门癌或食管癌的可切除性与T（CD3 +）和B（CD19 +）细胞亚群的变化有关。
