Fedele M, Bandiera A, Chiappetta G, Battista S, Viglietto G, Manfioletti G, Casamassimi A, Santoro M, Giancotti V, Fusco A
Instituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Itlay.
Cancer Res. 1996 Apr 15;56(8):1896-901.
A correlation has previously been demonstrated between the presence of the three HMGI proteins (HMGI, HMGY, and HMGI-C) and the expression of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells; this being subsequently extended to experimental thyroid, lung, prostate, mammary, and skin carcinomas. Recently, we have demonstrated that expression of HMGI and HMGY proteins, coded for by the HMGI(Y) gene, is associated with the malignant phenotype of human thyroid neoplasias. Here, we show that HMGI(Y) gene expression is present both at the RNA and protein level in human colorectal carcinoma cell lines and tissues examined in this study. Conversely, no HMGI(Y) proteins were detected in normal intestinal mucosa. Therefore, these results suggest an involvement of HMGI and HMGY proteins overexpression in colorectal tumorigenesis.
此前已证实，三种HMGI蛋白（HMGI、HMGY和HMGI-C）的存在与大鼠上皮和纤维母细胞甲状腺细胞中高度恶性表型的表达之间存在相关性；随后这一相关性扩展至实验性甲状腺癌、肺癌、前列腺癌、乳腺癌和皮肤癌。最近，我们证实由HMGI(Y)基因编码的HMGI和HMGY蛋白的表达与人类甲状腺肿瘤的恶性表型相关。在此，我们表明，在本研究检测的人类结肠癌细胞系和组织中，HMGI(Y)基因在RNA和蛋白质水平均有表达。相反，在正常肠黏膜中未检测到HMGI(Y)蛋白。因此，这些结果提示HMGI和HMGY蛋白过表达参与了结直肠癌的发生。
