Chiappetta G, Manfioletti G, Pentimalli F, Abe N, Di Bonito M, Vento M T, Giuliano A, Fedele M, Viglietto G, Santoro M, Watanabe T, Giancotti V, Fusco A
Istituto Nazionale dei Tumori di Napoli, Naples, Italy.
Int J Cancer. 2001 Jan 15;91(2):147-51. doi: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1033>3.3.co;2-m.
HMGI(Y) proteins are overexpressed in experimental and human malignancies, including colon, prostate and thyroid carcinomas. To determine at which step of the carcinogenic process HMGI(Y) induction occurs, we analysed the expression of the HMGI(Y) proteins in hyperplastic, preneoplastic and neoplastic tissues of colorectal origin by immunohistochemistry. All the colorectal carcinomas were HMGI(Y)-positive, whereas no expression was detected in normal colon mucosa tissue. HMGI(Y) expression in adenomas was closely correlated with the degree of cellular atypia. Only 2 of the 18 non-neoplastic polyps tested were HMGI(Y)-positive. These data indicate that HMGI(Y) protein induction is associated with the early stages of neoplastic transformation of colon cells and only rarely with colon cell hyperproliferation.
HMGI(Y)蛋白在实验性和人类恶性肿瘤中过度表达，包括结肠癌、前列腺癌和甲状腺癌。为了确定在致癌过程的哪个阶段发生HMGI(Y)诱导，我们通过免疫组织化学分析了结直肠来源的增生性、癌前和肿瘤组织中HMGI(Y)蛋白的表达。所有的结肠癌都是HMGI(Y)阳性，而在正常结肠黏膜组织中未检测到表达。腺瘤中HMGI(Y)的表达与细胞异型程度密切相关。在检测的18个非肿瘤性息肉中，只有2个是HMGI(Y)阳性。这些数据表明，HMGI(Y)蛋白诱导与结肠细胞肿瘤转化的早期阶段相关，而与结肠细胞过度增殖很少相关。
