Auwaerter P G, Hussey G D, Goddard E A, Hughes J, Ryon J J, Strebel P M, Beatty D, Griffin D E
Division of Infectious Diseases, Department of Medicine, John Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Clin Immunol Immunopathol. 1996 May;79(2):163-70. doi: 10.1006/clin.1996.0063.
Measles produces immune suppression which contributes to an increased susceptibility to other infections. Recently, high titered measles vaccines have been linked to increased long-term mortality among some female recipients. Because the mechanisms by which wild-type or attenuated live-vaccine strains of measles virus alter subsequent immune responses are not fully understood, this prompted an examination of the changes within the peripheral blood T cell receptor V beta repertoire following measles immunization. Twenty-four 6- and 9-month-old infants were studied at 2 weeks and 3 months following immunization by semiquantitative reverse transcription-polymerase chain reaction. There was a significant increase in V beta 2 expression (P less than 0.05), and a decrease in the V beta 4 subset (P less than 0.03) 2 weeks following vaccination with subsequent return to baselines at 3 months in vaccine recipients who seroconverted. These data suggest that measles virus may affect immune responses in part by altering the T cell receptor repertoire.
麻疹会导致免疫抑制，从而增加对其他感染的易感性。最近，高滴度麻疹疫苗与一些女性接种者的长期死亡率增加有关。由于野生型或减毒活疫苗株的麻疹病毒改变后续免疫反应的机制尚未完全了解，这促使人们对麻疹免疫后外周血T细胞受体Vβ谱的变化进行研究。通过半定量逆转录聚合酶链反应，对24名6个月和9个月大的婴儿在免疫后2周和3个月进行了研究。在血清转化的疫苗接种者中，接种疫苗2周后Vβ2表达显著增加（P<0.05），Vβ4亚群减少（P<0.03），3个月后恢复到基线水平。这些数据表明，麻疹病毒可能部分通过改变T细胞受体谱来影响免疫反应。
