Kubo T, Katsumata Y, Fukumori R, Taguchi K, Hagiwara Y
Department of Pharmacology, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Experientia. 1996 Apr 15;52(4):348-52. doi: 10.1007/BF01919539.
A conditioned stimulus previously paired with electric footshock produced an increase in blood pressure in conscious, freely moving rats. The conditioned pressor response was reproducible. Intracerebroventricular injection of the nicotinic receptor antagonists hexamethonium (1-10 micrograms) or pentolinium (10 micrograms) but not the muscarinic receptor antagonist methylatropine (3 micrograms) produced an inhibition of the conditioned pressor response, whereas intraarterial injection of hexamethonium (10 micrograms) did not affect the response. Intraventricular injection of the cholinesterase inhibitor physostigmine (3-10 micrograms) produced an enhancement of the conditioned pressor response. These results are consistent with the possibility that central nicotinic receptors play a role in the expression of the emotionally conditioned pressor response in rats.
先前与足部电击配对的条件刺激可使清醒、自由活动的大鼠血压升高。这种条件性升压反应具有可重复性。脑室内注射烟碱受体拮抗剂六甲铵（1 - 10微克）或喷托铵（10微克），而非毒蕈碱受体拮抗剂甲基阿托品（3微克），可抑制条件性升压反应，而动脉内注射六甲铵（10微克）则不影响该反应。脑室内注射胆碱酯酶抑制剂毒扁豆碱（3 - 10微克）可增强条件性升压反应。这些结果与中枢烟碱受体在大鼠情绪条件性升压反应的表达中起作用的可能性一致。
