Weigel M M, Calle A, Armijos R X, Vega I P, Bayas B V, Montenegro C E
Laboratorio de Inmunología, Facultad de Ciencias Médicas, Universidad Central de Ecuador, Quito.
Int J Gynaecol Obstet. 1996 Jan;52(1):9-17. doi: 10.1016/0020-7292(95)02442-5.
The main objective of this prospective cohort study was to investigate the prevalence, risk factors and maternal-perinatal consequences of chronic asymptomatic intestinal parasitic infection during pregnancy.
Prenatal patients (n=91) attending a public clinic in Quito, Ecuador, were followed during the third trimester. Intestinal parasitic, nutritional status, sociodemographic/sanitation indicators and fetal outcome data were collected and analyzed using multivariate ANOVA and regression techniques.
Most subjects (93%) were infected with at least one species of pathogenic intestinal parasite: 88% with Entamoeba histolytica. Greater parasite burdens were associated with poorer maternal iron status and reduced fetal growth. In particular, a high E. histolytica load was associated with decreased maternal serum hemoglobin (P=0.002) and hematocrit levels (P=0.01), iron deficiency anemia (P=0.026), and indicators of diminished intrauterine growth including a decreased ponderal index (P=0.04), mid-arm circumference (P=0.01), and mid-arm/head circumference ratio (P=0.003).
Asymptomatic intestinal parasitic infection represents a hidden risk factor for maternal iron deficiency anemia and fetal growth retardation.
这项前瞻性队列研究的主要目的是调查孕期慢性无症状肠道寄生虫感染的患病率、危险因素以及对母婴围产期的影响。
对厄瓜多尔基多一家公共诊所的产前患者（n = 91）在孕晚期进行随访。收集肠道寄生虫、营养状况、社会人口统计学/卫生指标及胎儿结局数据，并使用多因素方差分析和回归技术进行分析。
大多数受试者（93%）感染了至少一种致病性肠道寄生虫：88%感染溶组织内阿米巴。寄生虫负荷越高，产妇铁状态越差，胎儿生长受限越明显。特别是，高溶组织内阿米巴负荷与产妇血清血红蛋白水平降低（P = 0.002）、血细胞比容水平降低（P = 0.01）、缺铁性贫血（P = 0.026）以及包括体重指数降低（P = 0.04）、上臂围降低（P = 0.01）和上臂围/头围比降低（P = 0.003）等宫内生长受限指标相关。
无症状肠道寄生虫感染是产妇缺铁性贫血和胎儿生长迟缓的一个潜在危险因素。
